January 28th, 2023

BRUNO GRASSI, MD PhD

Professor of Physiology, FACSM, FAPS

 

 

CURRICULUM VITAE

 

Name:                              Bruno Grassi

Date of birth:                   January 6th 1958

Nationality:                     Italian

Family:                            Married, 2 son/daugther (born in 1992 and in 1995)

Home address:                 Viale Volontari della Libertà 4

                                        I – 33100 Udine

                                        Phone (mobile): +39-338-2762790

Work address:                 Department of Medicine

                                        University of Udine

                                        Piazzale M. Kolbe 4

                                        I - 33100 Udine

                                        Italy

                                        tel. +39-0432-494335, telefax +39-0432-494301

                                        e-mail: bruno.grassi [at] uniud.it

ORCID number: 0000-0003-3188-1659

 

EDUCATION

1976   High School Diploma, Carthage High School, Carthage, MO (USA), following a one-year scholarship by AFS International Scholarships.

1977   High School Diploma, Liceo Scientifico Statale “G.B. Grassi”, Saronno (VA), Italy.

1984   Medical Doctor, University of Milano, Italy.

1987   Postgraduate Specialization in Sports Medicine, University of Milano.

1992   PhD in Human Physiology, University of Milano (Supervisor Prof. Paolo Cerretelli).

 

ACADEMIC CAREER

1987            Research Scholarship, San Raffaele Hospital Scientific Institute, Milano.

1991–2001   Researcher, Institute of Advanced Biomedical Technologies, National Research Council, Milano.

2001–2007   Associate Professor of Physiology, School of Medicine, University of Milano.

2007–2010   Associate Professor of Physiology, School of Medicine, University of Udine, Italy.

Since 2010    Professor of Physiology, School of Medicine, University of Udine.

2013-2019    Associate Researcher, Institute of Bioimaging and Molecular Physiology, National Research Council, Milano.

 

OTHER APPOINTMENTS

2001-2007    Faculty Member, PhD School in Physiology, University of Milano.

Since 2008    Faculty Member, PhD School in Biomedical and Biotechnological Sciences, University of Udine.

2009–2010   Representative for Associate Professors, Board of Administrators, University of Udine.

2012-2017    Coordinator, Undergraduate School of Motor Sciences, University of Udine.

2013-2017    Coordinator, Postgraduate School of Sports Sciences, University of Udine.

Since Nov. 2017          Coordinator, School of Medicine, University of Udine

Since 2018    Member, Institutional Review Board, Department of Medicine, University of Udine

Since 2022    Director, Postgraduate School of Specialization in Sports Medicine, University of Udine.

 

PERIODS OF RESEARCH/TEACHING ABROAD

1992   Research Assistant, Dept. Physiologie, Universitè de Genève, Geneva (Switzerland) - (Prof. Paolo Cerretelli).

1993-1994    Visiting Scientist, Division of Physiology, Department ofMedicine, University of California at San Diego, La Jolla, CA (USA) – (Prof. Peter D. Wagner).

1996-1997    Postgraduate Researcher, Division of Physiology, Department ofMedicine, University of California at San Diego, La Jolla, CA (USA) – (Prof. Peter D. Wagner).

1998, 1999, 2000, 2001, 2002, 2004, 2005, 2009, 2016Visiting Scientist, Dept. Health and Human Performance, Auburn University, Auburn, AL (USA) (Prof. L.B. Gladden)

Nov. 2015, Visiting Professor, Universidade Federal de Santa Catarina, Florianopolis, Santa Catarina, Brasil.

Nov.-Dec. 2022        Visiting Professor, Department of Exercise Physiology and Muscle Bioenergetics, Faculty of Health Sciences, Jagiellonian University Medical College, Krakow, Poland.

 

PARTICIPATION TO INTERNATIONAL SCIENTIFIC EXPEDITIONS

1987, 1988    Siracusa (Italy): Physiological adaptations in elite breath-hold divers,

1989   Bipindi (Camerun): Energetics of locomotion in African pygmees.

1990, 1991    Ev-K2-CNR Scientific Expeditions, “Pyramid” Laboratory, Lobuche, Khumbu (Nepal): Aerobic and anaerobic energy metabolism at high altitude.

2007, 2008    Orthopedic Hospital, Valdoltra (Slovenia): Physiological adaptations to simulated microgravity (bed rest). Italian Space Agency (ASI) Project OSMA (Osteoporosis and Muscular Atrophy) - ASI-OSMA.

2012, 2013    Planica Sports Center, Ratece (Slovenia): Physiological adaptations to simulated microgravity (bed rest) and hypoxia. Research Project: “Planetary Habitat Simulation – PlanHab”. (VII Framework Programme, European Community, Bruxelles).

2012   Orthopedic Hospital, Valdoltra (Slovenia): Physiological adaptations to simulated microgravity (bed rest) in the elderly. Research Project: Physical activity and nutrition for quality ageing (PANGeA). Interreg-EU Projects.

2019   Bolnišnica Hospital, Izola (Slovenia): Effects of simulated microgravity (bed rest) on skeletal muscle oxidative metabolism. Research Project: “Marcatori biologici e funzionali per la biomedicine astronautica di precisione. MARS-PRE”. Italian Space Agency (Agenzia Spaziale Italiana, ASI).

 

HONORS

Since 2016    Fellow, American College of Sports Medicine (FACSM)

Since 2021    Fellow, Ameerican Physiological Society (FAPS)

 

RESEARCH ACTIVITY

 

General fields of interest:

Exercise and environmental physiology, skeletal muscle bioenergetics.

Specific fields of interest:

- Skeletal muscle oxidative metabolism during exercise; mechanisms of regulation; effects of training, inactivity, hypoxia, aging, pathological conditions.

- Functional evaluation of oxidative metabolism during exercise in humans, with specific reference to skeletal muscle: oxygen uptake kinetics, near-infrared spectroscopy, high-resolution respirometry in permeabilized skeletal muscle fibers; peripheral and microvascular function.

- Physiological adjustments to exercise and functional evaluation of skeletal muscle oxidative metabolism in elderly, heart transplant recipients, patients with chronic heart failure, transgenic mice models of cardiomyopathy, patients with metabolic myopathies, obese patients. Effects of training and other interventions.

- Effects of simulated microgravity and inactivity (bed rest) on skeletal muscle oxidative metabolism; effects of microgravity associated with hypoxia.

- Physiological adjustments and adaptations to exercise in chronic hypobaric hypoxia.

 

MAIN COLLABORATIONS

- Institute of Biomedical Technologies, National Research Council, Milano, Italy (Dr. M. Marzorati).

- Dept. Electronics, Informatics and Bioengineering, Politecnico of Milano, Italy (Prof. A. Aliverti).

– Laboratory of Ergonomy, Italian Auxological Institute, Milano and Piancavallo, Italy (Prof. A. Sartorio).

- Geriatric Clinic Unit, Dept. of Medicine and Surgery, University of Parma, Italy (Prof. M. Maggio).

- Center for Rare Diseases, Udine Academic Hospital, Udine, Italy (Prof. M. Scarpa).

- Dept. of Biomedical Science, University of Padua, Italy (Prof. M.V. Narici).

- Dept. of Molecular Medicine, University of Pavia, Italy (Prof. R. Bottinelli, Prof. M.A. Pellegrino, Prof. S. Porcelli).

- Dept. Exercise Physiology and Muscle Bioenergetics, Faculty of Health Sciences, Jagellonian University Medical College, Krakow, Poland (Prof. J.A. Zoladz).

- Institute for Kinesiology Research, Science and Research Center, Koper, Slovenia (Prof. R. Pišot).

- Dept. of Kinesiology, Auburn University, Auburn (Alabama), USA (Prof. L.B. Gladden).

- Dept. of Medicine, University of California San Diego, La Jolla (California), USA (Prof. M.C. Hogan).

- Division of Respiratory and Critical Care Physiology & Medicine, Harbor UCLA Medical Center, Torrance (California), USA (Prof. H.B. Rossiter).

- Dept. of Automation, Biocybernetics and Robotics, Jozef Stefan Institute, Ljubjana, Slovenia (Prof. I.B. Mekjavic).

- Dept. of Physiology, Nutrition & Biomechanics, Swedish School of Sport and Health Sciences, Stockholm, Sweden (Prof. D. Cardinale).

- Center of Sports, Federal University of Santa Catarina, Florianopolis, Brazil (Dr. Paulo Cesar do Nascimiento Salvador).

 

MAIN FUNDING RECEIVED FOR RESEARCH

      1998-2001. Project Coordinator. Collaborative Research Grant no. 972111, N.A.T.O., Bruxelles. Research Project: “Factors limiting muscle O2 uptake on-kinetics”. Obtained funding: 5500 €.

      1999-2001. Principal Investigator. Telethon Research Grant no. 1161 C: ”V’O2 kinetics for functional evaluation of myopathy patients”, Telethon Foundation, Italy. Obtained funding: 66.000 €.

      2001-2005. Scientific Coordinator of a Research Unit. Research Project: “Physical frailty and loss of functional independence in old age: determinants and adaptations to physical activity”. EC Contract n. QLK6-CT-2001-00323, V Framework Programme, European Community, Bruxelles. Total obtained funding: 1.602.561 €. Funding obtained for the Research Unit: 186720 €.

      2002-2005. Project Coordinator. Collaborative Linkage Grant no. LST.CLG.979220, N.A.T.O., Bruxelles. Research Project: “Skeletal muscle V’O2 kinetics: from basic physiology to exercise performance”. Obtained funding: 19200 €.

      2004-2006. Principal Investigator. Telethon – UILDM Project (GUP030534), Italy. “New tools of functional evaluation of patients with metabolic myopathies”. Obtained funding: 73975 €.

      2006-2008. Principal Investigator WorkPackage 1B32. Italian Space Agency (ASI) Project OSMA (Osteoporosis and Muscular Atrophy) - ASI-OSMA Contract I/007/06/0. “Functional evaluation of skeletal muscle oxidative metabolism in microgravity-induced muscular atrophy”. Obtained funding: 140000 €.

      2009-2011. Coordinator. Telethon – UILDM Project (GUP08007), Italy. “New methods of functional evaluation of patients with metabolic myopathies. The effects of exercise training”. Obtained funding: 117800 €.

      2011-2014. Participant to a Research Unit. Research Project: Physical activity and nutrition for quality ageing (PANGeA). Interreg-EU Projects. Total obtained funding: 1253000 €. Obtained funding for the Research Unit: 139000 €.

      2012-2014. Scientific Coordinator of a Research Unit. Research Project: “Planetary Habitat Simulation – PlanHab”. (EC Contract n. 284438, VII Framework Programme, European Community, Bruxelles; FP7-SPACE-2011-1. Total obtained funding: 1878973 €. Funding obtained for the Research Unit: 203064 €.

      2013-2016. Scientific Coordinator of the Italian Partners of the Project. Ministry for University and Research, Warsaw, Poland. Research Project: “The effect of endurance training on skeletal muscle adaptive responses in transgenic mice (Tgaq*44) with dilated cardiomyopathy”. Obtained funding for the Research Unit: 79000 €.

      2013-2017. Participant to a Research Unit. Ministry of Health, Italy.Progetti di Ricerca Finalizzata - Young Researchers, no. GR-2011-02348868. Research Project: “Exercise tolerance in patients with late-onset Pompe disease on enzyme replacement therapy: effects of exercise training and hyperproteic diet.” Obtained funding for the Research Unit: 35600 €.

      2017-2019. Co-funding for a post-doctoral fellowship. Istituto Auxologico Italiano, Milano. Project “Respiratory limitations to exercise tolerance in obese adolescents”. 19200 €.

  2019-2022. Coordinator of a Research Unit. PRIN 2017 Project (Italian Ministry of University and Research) 2017CBF8NJ, “Neuromuscular ageing: mechanisms and functional implications – NeuAge)”. Total obtained funding: 816860 €. Obtained funding for the Research Unit: 108120 €.

2019-2022. Coordinator of a Research Unit. Research Project: “Marcatori biologici e funzionali per la biomedicine astronautica di precisione. MARS-PRE”. Italian Space Agency (Agenzia Spaziale Italiana, ASI; Bando ASI DC-VUM-2017-006, Biomedicina). Total obtained funding: 1496000 €. Obtained funding for the Research Unit: 80000 €.

      2022-2025. Coordinator of a Research Unit. PRIN 2020 Project (Italian Ministry of University and Research) 2020EM9A8X, “Inactivity-induced neuromuscular impairment through different ages: from children, to young and middle age adults [InactivAge])”. Total obtained funding: 756931 €. Obtained funding for the Research Unit: 189688 €.

 

TOTAL OBTAINED FUNDING: about 1.500.000 €.

 

AFFILIATIONS TO SCIENTIFIC SOCIETIES

- Since 1997, Member, Italian Physiological Society

- Since 1999, Member, American Physiological Society

- Since 2002, Member, American College of Sports Medicine

- Since 2012, Fellow, American College of Sports Medicine

- 2006-2015, Member, Società Italiana di Biomedicina e Biotecnologia Spaziale

- Since 2016, Member, Physiological Society, UK

 

PARTICIPATION TO EVALUATING COMMITTEES, TOPICAL TEAMS, ETC.

      Since 2020. Member. European Space Agency (ESA) Topical Team on: “Pathophysiology, risk and clinical presentation of venous thromboembolism (VTE) and evaluation of its prevention, diagnosis, mitigation and management strategies in spaceflight”.

      Since 2020. Member. Tavolo Tematico Fisiologia Integrata (Cardiovascular Section). Italian Space Agency.

      2020. Reviewer. Austrian Research Fund (FWF).

      2021. Member of the Advisory Committee, Integrated Physiology of Exercise meeting, American College of Sports Medicine; Baltimore (USA); Sept. 21-24, 2022.

      2022. Reviewer. National Science Center, Poland.

 

EDITORIAL ACTIVITY

Editorial Board:

          Journal of Physiology (Reviewing Editor)

          Medicine and Science in Sports and Exercise (Associate Editor)

Guest Referee:

Journal of Applied Physiology, American Journal of Physiology (Heart and Circulatory Physiology); American Journal of Physiology (Regulatory, Integrative and Comparative Physiology); European Journal of Applied Physiology; Journal of Biomedical Optics; Experimental Physiology; Sports Medicine; Respiratory Physiology and Neurobiology; Circulation; Clinical Physiology and Functional Imaging; Acta Physiologica Scandinavica; Comprehensive Physiology; High Altitude Medicine and Biology; Scientific Reports.

 

MAIN TEACHING ACTIVITY (ACTUAL)

        Since Academic Year 2007-2008. “Human Physiology” course (145 hours). School of Medicine, University of Udine.

        2008-2016. “Human Physiology” course (30 hours). School of Physiotherapy, University of Udine.

        2011-2017. “Exercise Physiology” course (10 hours). Postgraduate Specialization Degree in Sports Medicine, University of Padova, Verona, Udine, Trieste.

        2011-2020. “Exercise Physiology” Course (16 hours). Undergraduate School of Motor Sciences, University of Udine.

        Since 2017. “Exercise Physiology” courses, 1 and 2 and 3 (30 hours). Postgraduate Specialization Degree in Sports Medicine, University of Trieste.

        Since 2021. “Physiology and patho-physiology of exercise tolerance” (40 hours). Graduate School of Sport Science, University of Udine.

        Since 2022. “Physiology and patho-physiology of exercise tolerance” (40 hours). Postgraduate Specialization Degree in Sports Medicine, University of Udine.

 

SUPERVISOR OF PhD STUDENTS

      1999-2002, Supervisor, PhD in Physiology, University of Milano. Dr. Silvia Pogliaghi: Thesis: “Noninvasive functional evaluation of muscle oxidative metabolism in healthy subjects and patients”.

      2003-2006, Co-supervisor. INSERM Motricité et Plasticité, Université de Bourgogne, Dijon (Francia) – University of Milano. Dr. Gaelle Deley. Thesis: “Desadaptation motrice et reconditionnement chez le patient insuffisant cardiaque”.

      2003-2006. Supervisor. PhD in Physiology, University of Milano. Dr. Francesca Lanfranconi. Thesis: «Exercise tolerance in heart transplant recipients: non-invasive evaluation of central and peripheral limiting factors to oxidative metabolism».

      2003-2006. Supervisor. PhD in Physiology, University of Milano. Dr. Miriam Longaretti. Thesis: «Oxidative metabolism during exercise in the elderly: limiting factors and adaptations».

      2004-2007. Supervisor. PhD in Physiology, University of Milano. Dr. Stefano Mazzoni. Thesis: “Physiological adjustments to exercise in grinders participating to sailing America’s Cup: a comparison between upper and lower limbs».

      2004-2007. Supervisor. PhD in Physiology, University of Milano. Dr. Paola Vago. Thesis: “Non-invasive functional evaluation of oxidative metabolism in patients with metabolic myopathies”.

      2007-2011. Supervisor. PhD in Biomedical Sciences and Biotechnology, University of Udine. Dr. Desy Salvadego. Thesis: “Functional evaluation of oxidative metabolism in health and disease. An integrative approach.”

      2011-2015. Supervisor. PhD in Biomedical Sciences and Biotechnology, University of Udine. Dr. Simone Porcelli. Thesis: “Functional evaluation of muscle oxidative metabolism in metabolic myopathies. A cross-talk between exercise physiology and clinical medicine.”

      2012-2016. Supervisor. PhD in Biomedical Sciences and Biotechnology, University of Udine. Dr. Annalisa Sechi. Thesis: “Exercise physiology applied to the evaluation of exercise tolerance in patients with late-onset Pompe disease.”

      2012-2016. Co-supervisor. PhD in Biomedical Sciences and Biotechnology, University of Udine. Dr. Alessia Buso. Thesis: “Mitochondrial oxidative phosphorylation plasticity/adaptation triggered by disturbances and stresses and targeted by therapies.”

      2013-2017. Supervisor. PhD in Biomedical Sciences and Biotechnology, University of Udine. Dr. Lea Biasutti. Thesis: “Functional evaluation of exercise tolerance and oxidative metabolism in patients with spinal cord injury and Pompe disease.”

      2014-2018. Supervisor. PhD in Biomedical Sciences and Biotechnology, University of Udine. Dr. Hailu Kinfu Alemayehu. Thesis: “Respiratory limitations to exercise tolerance and performance in obese adolescent patients”.

      2016–2019. Co-supervisor. PhD in Biomedical Sciences and Biotechnology, University of Udine. Dr. Benedetta Magnesa. Thesis: “Skeletal muscle mitochondrial oxidative phosphorylation plasticity in two studies on humans: exercise training effects in obese subjects and bed rest effect in healthy subjects”.

      2017- 2021. Supervisor. PhD in Biomedical Sciences and Biotechnology, University of Udine. Dr. Lucrezia Zuccarelli. Thesis: “New approaches of functional evaluation of oxidative metabolism during exercise, with special reference to the effects of inactivity – microgravity (bed rest)”.

      2018- 2022. Co-supervisor. PhD in Biomedical Sciences and Biotechnology, University of Udine. Dr. Andrea Pilotto. Thesis: “Mitochondrial memory at skeletal muscle level”.

      2019- today. Supervisor. PhD in Biomedical Sciences and Biotechnology, University of Udine. Mr. Giovanni Baldassarre.

      2019- today. Co-Supervisor. PhD in Biomedical Sciences and Biotechnology, University of Udine. Ms. Clarissa Gissi.

      2021 – today. Co-Supervisor. PhD in Biomedical Sciences and Biotechnology, University of Udine. Ms. Caterina Ursella.

 

EXTERNAL EXAMINER OF PhD CANDIDATES

2004. Dr. Darren De Lorey, University of Western Ontario, London, Ontario, Canada.

2006. Dr. Aurélien Bringard, Université de Montpellier, Montpellier, France.

2007. Dr. Ronald D. Kooistra, Vrije University, Amsterdam, The Netherlands.

2010. Dr. Alessandra Adami, University of Verona, Verona, Italy.

2012. Dr. Scott Bowen, University of Leeds, Leeds, United Kingdom.

2017. Dr. Jorge L. Storniolo, University of Milano, Milano, Italy.

2018. Dr. Angela Valentina Bisconti, University of Milano, Milano, Italy.

2020. Dr. Oyvind Skattebo, University of Oslo, Oslo, Norway.

2021. Dr. Giovanni Vinetti, University of Brescia, Italy.

2020. Dr. Frédérick Stucky, Université de Lausanne, Lausanne, Switzerland.

2021. Dr. Adam Alexander Lucero, Massey University, Wellington, New Zealand.

2022. Dr. Gabriele Marinari. University of Calgary, Calgary, Canada.

2022. Dr. Maira Rossi. University of Pavia, Pavia, Italy.

 

 

LIST OF PUBLICATIONS

 

A)  PUBLICATIONS ON INTERNATIONAL AND PEER-REVIEWED SCIENTIFIC JOURNALS

(Google Scholar: January 2023: H-index = 55, total number of citations = 9667;

Scopus: November 2022: H-index 43, total number of citations = 6469)

 

    1. Cerretelli P., B. Grassi, A. Colombini, B. Carù, C. Marconi. Gas exchange and metabolic transients in heart transplant recipients. Respir. Physiol. 74: 355-371, 1988.

    2. Ferretti G., G. Atchou, B. Grassi, C. Marconi, P. Cerretelli. Energetics of locomotion in african pygmies. Eur. J. Appl. Physiol. 62: 7-10, 1991.

    3. Grassi B., P. Cerretelli, M.V. Narici, C. Marconi. Peak anaerobic power in master athletes. Eur. J. Appl. Physiol. 62: 394-399, 1991.

    4. Ferretti G., M. Costa, M. Ferrigno, B. Grassi, C. Marconi, C.E.G. Lundgren, P. Cerretelli. Alveolar gas composition and exchange during deep breath-hold diving and dry breath-holds in elite divers. J. Appl. Physiol. 70: 794-802, 1991.

    5. Marconi C., B. Grassi, M. Meyer, A. Cabrol, P. Cerretelli. Ventilatory and gas exchange kinetics in a human recipient of a Jarvik-7 total artificial heart. J. Appl. Physiol. 70: 1406-1407, 1991.

    6. Ferrigno M., B. Grassi, G. Ferretti, M. Costa, C. Marconi, P. Cerretelli, C.E.G. Lundgren. ECG during deep breath-hold dives by elite divers. Undersea Biomed. Res. 18: 81-91, 1991.

    7. Meyer M., C. Marconi, B. Grassi, P. Cerretelli, C. Cabrol. Adjustment of cardiac output to step exercise in heart transplant recipients. Appl. Cardiopulm. Pathophysiol. 4: 213-223, 1992.

    8. Cerretelli P., C. Marconi, M. Meyer, G. Ferretti, B. Grassi. Gas exchange kinetics in heart transplant recipients. Chest 101 (Suppl. 1): 199S-205S, 1992.

    9. Grassi B., G. Ferretti, L. Xi, M. Rieu, M. Meyer, C. Marconi, P. Cerretelli. Ventilatory response to exercise after heart and lung denervation in humans. Respir. Physiol. 92: 289-304, 1993.

    10. Kayser B., M. Narici, S. Milesi, B. Grassi, P. Cerretelli. Body composition and maximum alactic anaerobic performance during a one month stay at high altitude. Int. J. Sports Med. 14: 244-247, 1993.

    11. Kayser B., G. Ferretti, B. Grassi, T. Binzoni, P. Cerretelli. Maximal lactic capacity at altitude: effects of bicarbonate loading. J. Appl. Physiol. 75: 1070-1074, 1993.

    12. Richardson R.S., D.C. Poole, D.R. Knight, S.S. Kurdak, M.C. Hogan, B. Grassi, E.C. Johnson, K. Kendrick, B.K. Erickson, P.D. Wagner. High muscle blood flow in man: is maximal O2 extraction compromised? J. Appl. Physiol. 75: 1911-1916, 1993.

    13. Cerretelli P., L. Xi, F. Schena, C. Marconi, B. Grassi, G. Ferretti, M. Meyer. Ventilatory response at the onset of exercise. An update of the neurohumoral theory. Adv. Exp. Med. Biol. 337: 327-332, 1993.

    14. Grassi B., G. Ferretti, M. Costa, C. Marconi, P. Cerretelli. Chemoreflexogenic ventilatory drive in humans adapted to unusual environments. Adv. Exp. Med. Biol. 337: 353-357, 1993.

    15. Kayser B., T. Binzoni, M.V. Narici, B. Grassi, P. Cerretelli. Fatigue and exhaustion in chronic hypobaric hypoxia: influence of exercising muscle mass. J. Appl. Physiol. 76: 634-640, 1994.

    16. Meyer M., A. Rahmel, C. Marconi, B. Grassi, P. Cerretelli, C. Cabrol. Adjustment of cardiac output to step exercise in heart transplant recipients. Z. Kardiol. 83 (Suppl. 3): 103-109, 1994.

    17. Grassi B., G. Ferretti, M. Costa, M. Ferrigno, A. Panzacchi, C.E.G. Lundgren, C. Marconi, P. Cerretelli. Ventilatory responses to hypercapnia and hypoxia in elite breath-hold divers. Respir. Physiol. 97: 323-332, 1994.

    18. Richardson R.S., D.R. Knight, D.C. Poole, S.S. Kurdak, M.C. Hogan, B. Grassi, P.D. Wagner. Determinants of maximal exercise V’O2 during single leg knee-extensor exercise in humans. Am. J. Physiol. 268: (Heart Circ. Physiol. 37): H1453-H1461, 1995.

    19. Grassi B., G. Ferretti, B. Kayser, M. Marzorati, A. Colombini, C. Marconi, P. Cerretelli. Maximal rate of blood lactate accumulation during exercise at altitude in humans. J. Appl. Physiol. 79: 331-339, 1995.

    20. Cerretelli P., B. Grassi, L. Xi, F. Schena, C. Marconi, M. Meyer, G. Ferretti. The role of pulmonary CO2 flow in the control of the "phase I" ventilatory response to exercise in humans. Eur. J. Appl. Physiol. 71: 287-294, 1995.

    21. Kurdak S.S., B. Grassi, P.D. Wagner, M.C. Hogan. Effect of [Hb] on blood flow distribution and O2 transport in maximally working skeletal muscle. J. Appl. Physiol. 79: 1729-1735, 1995.

    22. Grassi B., M. Marzorati, B. Kayser, M. Bordini, A. Colombini, M. Conti, C. Marconi, P. Cerretelli. Peak blood lactate and blood lactate vs. work load during acclimatization to 5,050 m and in the deacclimatization. J. Appl. Physiol. 80: 685-692, 1996.

    23. Grassi B., D.C. Poole, R.S. Richardson, D.R. Knight, B.K. Erickson, P.D. Wagner. Muscle O2 uptake kinetics in humans: implications for metabolic control. J. Appl. Physiol. 80: 988-998, 1996. (September 2017: 17th most cited article of the Journal of Applied Physiology).

    24.Kurdak S.S., B. Grassi, P.D. Wagner, M.C. Hogan. Blood flow distribution in working in situ canine muscle during blood flow reduction. J. Appl. Physiol. 80: 1978-1983, 1996.

    25. Eldridge M.W., A. Podolsky, R.R. Richardson, D.H. Johnson, D.R. Knight, E.C. Johnson, S.R. Hopkins, H. Michimata, B. Grassi, J. Feiner, S.S. Kurdak, P.E. Bickler, P.D. Wagner, J.W. Severinghaus. Pulmonary hemodynamic response to exercise in subjects with prior high-altitude pulmonary edema. J. Appl. Physiol. 81: 911-921, 1996.

    26. Podolsky A., M.W. Eldridge, R.S. Richardson, D.R. Knight, E.C. Johnson, S.R. Hopkins, D.H. Johnson, H. Michimata, B. Grassi, J. Feiner, S.S. Kurdak, P.E. Bickler, J.W. Severinghaus, P.D. Wagner. Exercise induced V’A/Q’ inequality in subjects with prior high altitude pulmonary edema. J. Appl. Physiol. 81: 922-932, 1996.

    27. Grassi B., C. Marconi, M. Meyer, M. Rieu, P. Cerretelli. Gas exchange and cardiovascular kinetics upon different exercise protocols in heart transplant recipients. J. Appl. Physiol. 82: 1952-1962, 1997.

    28. Meyer M., A. Rahmel, C. Marconi, B. Grassi, J.E. Skinner, P. Cerretelli. Is the heart preadapted to hypoxia? Evidence from fractal dynamics of heartbeat interval fluctuations at high altitude (5,050 m). Int. Physiol. Behav. Sci. 33: 9-40, 1998.

    29. Hogan M.C., L.B. Gladden, B. Grassi, C.M. Stary, M. Samaja. Bioenergetics of contracting skeletal muscle after partial reduction of blood flow. J. Appl. Physiol. 84: 1882-1888, 1998.

    30. Grassi B., L. B. Gladden, M. Samaja, C.M. Stary, M.C. Hogan. Faster adjustment of O2 delivery does not affect V’O2 on-kinetics in isolated in situ canine muscle. J. Appl. Physiol. 85: 1394-1403, 1998.

    31. Grassi B., L.B. Gladden, C.M. Stary, P.D. Wagner, M.C. Hogan. Peripheral O2 diffusion does not affect V’O2 on-kinetics in isolated in situ canine muscle. J. Appl. Physiol. 85: 1404-1412, 1998.

    32. Meyer M., A. Rahmel, C. Marconi, B. Grassi, P. Cerretelli, J.E. Skinner. Stability of heartbeat interval distributions in chronic high altitude hypoxia. Int. Physiol. Behav. Sci. 33: 344-362, 1998.

    33. Samaja M., S. Allibardi, G. Milano, G. Neri, B. Grassi, L.B. Gladden, M.C. Hogan. Differential depression of myocardial function and metabolism by lactate and H+. Am. J. Physiol. 276 (Heart Circ. Physiol.): H3-H8, 1999.

    34. Richardson R.S., B. Grassi, T.P. Gavin, L.J. Haseler, K. Tagore, J. Roca, P.D. Wagner. Evidence of O2 supply-dependent V’O2max in the exercise-trained human quadriceps. J. Appl. Physiol. 86: 1048-1053, 1999.

    35. Cibella F., G. Cuttitta, S. Romano, B. Grassi, G. Bonsignore, J. Milic-Emili. Respiratory energetics during exercise at high altitude. J. Appl. Physiol. 86: 1785-1792, 1999.

    36. Grassi B., V. Quaresima, C. Marconi, M. Ferrari, P. Cerretelli. Blood lactate accumulation and muscle deoxygenation during incremental exercise. J. Appl. Physiol. 87: 348-355, 1999.

    37. Grassi B. Skeletal muscle V’O2 on-kinetics: set by O2 delivery or by O2 utilization? New insights into an old issue. Med. Sci. Sports Exerc. 32: 108-116, 2000.

    38. Richardson R.S., C.A. Harms, B. Grassi, R.T. Hepple. Skeletal muscle: master or slave of the cardiovascular system? Med. Sci. Sports Exerc. 32: 89-93, 2000.

    39. Grassi B., M.C. Hogan, K.M. Kelley, W.G. Aschenbach, J.J. Hamann, R.K. Evans, R.E. Patillo, L.B. Gladden. Role of convective O2 delivery in determining V’O2 on-kinetics in canine muscle contracting at peak V’O2. J. Appl. Physiol. 89: 1293-1301, 2000.

    40. Cerretelli P., B. Grassi. Gas exchange, MRS and NIRS assessment of metabolic transients in skeletal muscle. Amer. Zool. 41: 229-246, 2001.

    41. Grassi B., P. Mognoni, M. Marzorati, S. Mattiotti, C. Marconi, P. Cerretelli. Power and peak blood lactate at 5,050 m with 10 and 30 s “all out” cycling. Acta Physiol. Scand. 172: 189-194, 2001.

    42. Grassi B. Regulation of oxygen consumption at exercise onset. Is it really controversial? Exerc. Sport Sci. Rev. 29: 134-138, 2001.

    43. Grassi B., M.C. Hogan, P.L. Greenhaff, J.J. Hamann, K.M. Kelley, W.G. Aschenbach, D. Constantin-Teodosiu, L.B. Gladden. V’O2 on-kinetics in dog gastrocnemius in situ following activation of pyruvate dehydrogenase by dichloroacetate. J. Physiol. 538: 195-207, 2002.

    44. Fukuoka Y., B. Grassi, M. Conti, D. Guiducci, M. Sutti, C. Marconi, P. Cerretelli. Early effects of exercise training on V’O2 on- and off-kinetics in 50 yr old subjects. Pflüg. Arch. 443: 690-697, 2002.

    45. Itoh M., Y. Fukuoka, B. Grassi, C. Marconi, P. Cerretelli, H. Araki, K. Nishi. VE response to V’CO2 during exercise is unaffected by exercise training and different exercising limbs. Jpn. J. Physiol. 52:489-496, 2002.

    46. Grassi B., S. Pogliaghi, S. Rampichini, V. Quaresima, M. Ferrari, C. Marconi, P. Cerretelli. Muscle oxygenation and gas exchange kinetics during cycling exercise on- transition in humans. J. Appl. Physiol. 95: 149-158, 2003.

    47. Hogan M.C., B. Grassi, M. Samaja, C.M. Stary, L.B. Gladden. Effect of contraction frequency on the contractile and non-contractile phases of muscle venous blood flow. J. Appl. Physiol. 95: 1139-1144, 2003.

    48. Grassi B. Oxygen uptake kinetics: old and recent lessons from experiments on isolated muscle in situ. Eur. J. Appl. Physiol. 90: 242-249, 2003.

    49. Borrelli E., S. Pogliaghi, A. Molinello, F. Diciolla, M. Maccherini, B. Grassi. Serial assessment of peak V’O2 and V’O2 kinetics early after heart transplantation. Med. Sci. Sports Exerc. 35: 1798-1804, 2003.

    50. Marconi C., M. Marzorati, B. Grassi, B. Basnyat, A. Colombini, B. Kayser, P. Cerretelli. Second generation Tibetan lowlanders acclimatise to high altitude more quickly than Caucasians. J. Physiol. 556: 661-671, 2004.

    51. Deley G., G. Kervio, B. Verges, A. Hannequin, M.-F. Petitdant, S. Salmi-Belmihoub, B. Grassi, J.-M. Casillas. Comparison of low-frequency electrical stimulation and conventional exercise training in patients with chronic heart failure. Eur. J. Cardiov. Prev. Rehabil. 12: 226-233, 2005.

    52. Grassi B. Delayed metabolic activation of oxidative phosphorylation in skeletal muscle at exercise onset. Med. Sci. Sports Exerc. 37: 1567-1573, 2005.

    53. Grassi B., M.C. Hogan, K.M. Kelley, R.A. Howlett, L.B. Gladden. Effects of NOS inhibition by L-NAME on oxygen uptake kinetics in isolated canine muscle in situ. J. Physiol. 568: 1021-1033, 2005.

    54. Howlett R.A., K.M. Kelley, B. Grassi, L.B. Gladden, M.C. Hogan. Caffeine administration results in greater tension development in previously fatigued canine muscle in situ. Exp. Physiol. 90: 873-879, 2005.

    55. Ferri A., M. Narici, B. Grassi, M. Pousson. Neuromuscular recovery after a strength training session in elderly people. Eur. J. Appl. Physiol. 97: 272-279, 2006.

    56. Lanfranconi F., E. Borrelli, A. Ferri, S. Porcelli, M. Maccherini, M. Chiavarelli, B. Grassi. Non-invasive evaluation of skeletal muscle oxidative metabolism after heart transplant. Med. Sci. Sports Exerc. 38: 1374-1383, 2006.

    57. Grassi B., M.C. Hogan, L.B. Gladden. Nitric oxide and skeletal muscle V’O2 kinetics. J. Physiol. 573. 565-566, 2006.

    58. Gelfi C., A. Viganò, M. Ripamonti, A. Pontoglio, S. Begum, M.A. Pellegrino, B. Grassi, R. Bottinelli, R. Wait, P. Cerretelli. The human muscle proteome in aging. J. Proteome Res. 5: 1344-1353, 2006.

    59. Morandi L., C. Angelini, A. Prelle, A. Pini, B. Grassi, G. Bernardi, L. Politano, C. Bruno, D. De Grandis, P. Cudia, A. Citterio. High plasma creatine kinase: review of the literature and proposal for a diagnostic algoithm. Neurol. Sci. 27: 303-311, 2006.

    60. Grassi B. Oxygen uptake kinetics: why are they so slow? And what do they tell us? J. Physiol. Pharmacol. 57 (Suppl. 10): 53-65, 2006.

    61. Zoladz J.A., B. Korzeniewski, B. Grassi. Training-induced acceleration of oxygen uptake kinetics in skeletal muscle: the underlying mechanisms. J. Physiol. Pharmacol. 57 (Suppl. 10): 67-84, 2006.

    62. Grassi B., M. Marzorati, F. Lanfranconi, A. Ferri, M. Longaretti, A. Stucchi, P. Vago, C. Marconi, L. Morandi. Impaired oxygen extraction in metabolic myopathies: detection and quantification by near-infrared spectroscopy. Muscle Nerve 35: 510-520, 2007.

    63. Grassi B., M. Marzorati, B. Kayser, C. Marconi, P. Cerretelli. Comments on Point/Counterpoint: The lactate paradox does/does not occur during exercise at high altitude. J. Appl. Physiol. 102: 2404-2405, 2007 (Letter to the Editor).

    64. Ferri A., S. Adamo, M. Longaretti, M. Marzorati, F. Lanfranconi, A. Marchi, B. Grassi. Insights into central and peripheral factors affecting the “oxidative performance” of skeletal muscle in aging. Eur. J. Appl. Physiol. 100: 571-579, 2007.

    65. Deley G., G. Kervio, J. Van Hoecke, B. Verges, B. Grassi, J.M. Casillas. Effects of a one-year exercise training program in adults over 70 years old: a study with a control group. Aging Clin. Exp. Res. 19: 310-315, 2007.

    66. Lai N., G.M. Saidel, B. Grassi, L.B. Gladden, M.E. Cabrera. Model of oxygen transport and metabolism predicts effect of hyperoxia on canine muscle oxygen uptake dynamics. J. Appl. Physiol. 103: 1366-1378, 2007.

    67. Grassi B., F. Lanfranconi, S. Porcelli, A. Ferri, E. Borrelli. Comments on Point/Counterpoint: Cardiac denervation does/does not play a major role in exercise limitation after heart transplantation. J. Appl. Physiol. 104: 566, 2008 (Letter to the Editor).

68. Deley G., G. Kervio, B. Verges, A. Hannequin, M.F. Petitdant, B. Grassi, J.M. Casillas. Neuromuscular adaptations to low-frequency stimulation training in a patient with chronic heart failure. Am. J. Phys. Med. Rehabil. 87: 502-509, 2008.

69. Zoladz J.A., L.B. Gladden, M.C. Hogan, Z. Nieckarz, B. Grassi. Progressive recruitment of muscle fibers is not necessary for the slow component of V’O2 kinetics. J. Appl. Physiol. 105: 575-580, 2008.

70. Grassi B. Reduced skeletal muscle recruitment does not explain the lactate paradox. J. Appl. Physiol. 106: 741, 2009 (Letter to the Editor).

71. Grassi B., L.B. Gladden, M.C. Hogan, J.A. Zoladz. Is progressive recruitment of muscle fibers required for the slow component of V’O2 kinetics? J. Appl. Physiol. 106: 747, 2009. (Letter to the Editor).

72. Grassi B., S. Porcelli, M. Marzorati, F. Lanfranconi, P. Vago, C. Marconi, L. Morandi. Metabolic myopathies: functional evaluation by analysis of oxygen uptake kinetics. Med. Sci. Sports Exerc. 41: 2120-2127, 2009.

73. Grassi B. Time-delayed phases of V’O2 kinetics: evidences from an animal model and functional relevance. J. Appl. Physiol. 107: 1673, 2009. (Letter to the Editor).

74. di Prampero P.E., D. Salvadego, S. Fusi, B. Grassi. A simple method for assessing the energy cost of running during incremental tests. J. Appl. Physiol. 107: 1068-1075, 2009.

75. D’Agostino B., M. Polverino, G. Cirino, A. Lombardi, B. Grassi, N. Sullo, C. Santoriello, F. Polverino, D. Orlotti, M. Matteis, F. Rossi. Exercise capacity and cytochrome oxidase activity in muscle mitochondria of COPD patients. Respir. Med. 104: 83-90, 2010.

76. Porcelli S., M. Marzorati, F. Lanfranconi, P. Vago, R. Pišot, B. Grassi. Role of skeletal muscle impairment and brain oxygenation in limiting oxidative metabolism during exercise after bed rest. J. Appl. Physiol. 109: 101-111, 2010.

77. Mezzani A., B. Grassi, A. Giordano, U. Corrà, S. Colombo, P. Giannuzzi. Age-related prolongation of phase I of V’O2 on-kinetics in healthy humans. Am. J. Physiol. (Regul. Int. Comp. Physiol.) 299: R968-R976, 2010.

78. Salvadego D., S. Lazzer, C. Busti, R. Galli, F. Agosti, C. Lafortuna, A. Sartorio, B. Grassi. Gas exchange kinetics in obese adolescents. Inferences on exercise tolerance and prescription. Am. J. Physiol. (Regul. Int. Comp. Physiol.) 299: R1298-R1305, 2010.

79. Grassi B., H.B. Rossiter, M.C. Hogan, R.A. Howlett, J.E. Harris, M.L. Goodwin, J.L. Dobson, L.B. Gladden. Faster O2 uptake kinetics in canine skeletal muscle in situ after acute creatine kinase inhibition. J. Physiol. 589: 221-233, 2011.

80. Grassi B., S. Porcelli, D. Salvadego, J.A. Zoladz. Slow V’O2 kinetics during moderate-intensity exercise as markers of lower metabolic stability and lower exercise tolerance. Eur. J. Appl. Physiol. 111: 345-355, 2011.

81. Zoladz J.A., J. Majerczak J, B. Grassi. The highest possible skeletal muscle metabolic stability as a key factor for breaking the 2-hour marathon barrier. J. Appl. Physiol. 110: 291, 2011 (Letter to the Editor).

82. Jones A.M., B. Grassi, P.M. Christensen, P. Krustrup, J. Bangsbo, D.C. Poole. The slow component of V’O2 kinetics: mechanistic bases and practical applications. Med. Sci. Sports Exerc. 43: 2046-2062, 2011.

83. Wüst C.I., B. Grassi, M.C. Hogan, R.A. Howlett, L.B. Gladden, H.B. Rossiter. Kinetic control of oxygen consumption during contractions in self-perfused skeletal muscle. J. Physiol. 589: 3995-4009, 2011.

84. Salvadego D., S. Lazzer, M. Marzorati, S. Porcelli, E. Rejc, B. Šimunic, R. Pišot, P.E. di Prampero, B. Grassi. Functional impairment of skeletal muscle oxidative metabolism during knee-extension exercise after bed rest. J. Appl. Physiol.111: 1719-1726, 2011.

85. Wüst C.I., B. Grassi, M.C. Hogan, R.A. Howlett, L.B. Gladden, H.B. Rossiter. Implications of rapid oxygen consumption in exercising skeletal muscle: The empirical, the theoretical and the rational. J. Physiol. 589: 6245-6246, 2011.

86. Mezzani A., F. Pisano, A. Cavalli, M.A. Tommasi, U. Corrà, S. Colombo, B. Grassi, M. Marzorati, S. Porcelli, L. Morandi, P. Giannuzzi. Reduced exercise capacity in early-stage amyotrophic lateral sclerosis: role of skeletal muscle. Amyotroph. Lateral. Scl. 13: 87-94, 2012.

87. Marzorati M., S. Porcelli, B. Reggiori, L. Morandi, B. Grassi. Improved exercise tolerance adter enzyme replacement therapy in Pompe disease. Med. Sci. Sports Exerc. 44: 771-775, 2012.

88. Zoladz J.A., Z. Szkutnik, J. Majerczak, M. Grandys, K. Duda, B. Grassi. Isometric strength training lowers the O2 cost of cycling during moderate-intensity exercise. Eur. J. Appl. Physiol. 112: 4151-4161, 2012.

89. Porcelli S., M. Marzorati, L. Pugliese, S. Adamo, J. Gondin, R. Bottinelli, B. Grassi. Lack of functional effects of neuromuscular electrical stimulation on skeletal muscle oxidative metabolism in healthy humans. J. Appl. Physiol.113: 1101-1109, 2012.

90. Spires J., L.B. Gladden, B. Grassi, G. Saidel, N. Lai. Model analysis of the relationship between intracellular PO2 and energy demand in skeletal muscle. Am. J. Physiol. Reg. Int. Comp. Physiol. 303: R1110-R1126, 2012.

91. Marzorati M., S. Porcelli, G. Bellistri, L. Morandi, B. Grassi. Exercise testing in late-onset glycogen storage disease type II patients undergoing enzyme replacement therapy. Neuromusc. Dis. 22 (Suppl. 3): S230-S234, 2012.

92. Zoladz J.A., B. Grassi, J. Majerczak, Z. Szkutnik, M. Korostyński, J. Karasiński, W. Kilarski, B. Korzeniewski. Training-induced acceleration of V’O2 on-kinetics precedes muscle mitochondrial biogenesis in humans. Exp. Physiol. 98: 883-898, 2013.

93. Salvadego D., R. Domenis, S. Lazzer, S. Porcelli, J. Rittweger, G. Rizzo, I. Mavelli, B. Šimunic, R. Pišot, B. Grassi. Skeletal muscle oxidative function in vivo and ex vivo in athletes with marked hypertrophy from resistance training. J. Appl. Physiol. 114: 1527-1535, 2013.

94. Lazzer S., D. Salvadego, S. Porcelli, E. Rejc, F. Agosti, A. Sartorio, B. Grassi. Skeletal muscle oxygen uptake in obese patients: functional evaluation by knee extension exercise. Eur. J. Appl. Physiol.113: 2125-2132, 2013.

95. Spires J., L.B. Gladden, B. Grassi, G.M. Saidel, M.L. Goodwin, N. Lai. Distinguishing the effects of convective and diffusive O2 delivery on V’O2 on kinetics in skeletal muscle contracting at moderate intensity. Am. J. Physiol. Regul. Integr. Comp. Physiol. 305: R512-R521, 2013.

96. Benson A.P., B. Grassi, H.B. Rossiter. A validated model of oxygen uptake and circulatory dynamic interactions at exercise onset in humans. J. Appl. Physiol. 115: 743-755, 2013.

97. Mezzani A., B. Grassi, A.M. Jones, A. Giordano, U. Corrà, S. Porcelli, S. Della Bella, A. Tedesco, P. Giannuzzi. Speeding of pulmonary V’O2 on-kinetics by light-to-moderate intensity aerobic exercise training in chronic heart failure: clinical and pathophysiological correlates. Int. J. Cardiol. 167: 2189-2195, 2013.

98. Lazzer S., P. Taboga, D. Salvadego, E. Rejc, B. Šimunic, M.V. Narici, A. Buglione, N. Giovanelli, G. Antonutto, B. Grassi, R. Pišot, P.E. di Prampero. Factors affecting the energy cost of running during an ultra-endurance race. J. Exp. Biol. 217: 787-795, 2014.

99. Porcelli S., M. Marzorati, M. Belletti, G. Bellistri, L. Morandi, B. Grassi. The “second wind” in McArdle’s disease patients during a second bout of constant work rate submaximal exercise. J. Appl. Physiol. 116: 1230-1237, 2014.

100. Zoladz J.A., B. Grassi, J. Majerczak, Z. Szkutnik, M. Korostynski, M. Grandys, W. Jarmuszkiewicz, B. Korzeniewski. Mechanisms responsible for the acceleration of pulmonary V’O2 on-kinetics in humans after prolonged exercise training. Am. J. Physiol. Reg. Integr. Comp. Physiol. 307: 1101-1114, 2014.

101. Salvadego D., A. Sartorio, F. Agosti, G. Tringali, A. Patrizi, A. LoMauro, A. Aliverti, B. Grassi. Acute respiratory muscle unloading by normoxic helium-O2 breathing reduces the O2 cost of cycling and perceived exertion in obese adolescents. Eur. J. Appl. Physiol. 115: 99-109, 2015.

102. Rejc E., P.E. di Prampero, S. Lazzer, B. Grassi, B. Šimunic, R. Pišot, G. Antonutto, M. Narici. Maximal explosive power of the lower limbs before and after 35 days of bed rest under different diet energy intake. Eur. J. Appl. Physiol. 115: 429-436, 2015.

103. Cannavino J., L. Brocca, M. Sandri, B. Grassi, R. Bottinelli, M.A. Pellegrino. The role of alterations in mitochondrial dynamics and PCG-1a over-expression in fast muscle atrophy following hindlimb unloading. J. Physiol. 593: 1981-1995, 2015.

104. Rejc E., P.E. di Prampero, S. Lazzer, B. Grassi, B. Šimunic, R. Pišot, G. Antonutto, M. Narici. A 35-day bed rest does not alter the bilateral deficit of the lower limbs during explosive efforts. Eur. J. Appl. Physiol. 115: 1323-1330, 2015.

105. Lazzer S., D. Salvadego, P. Taboga, E. Rejc, N. Giovanelli, G. Antonutto, B. Grassi, P.E. di Prampero. Effects of the Etna uphill ultra-marathon on energy cost and mechanics of running. Int. J. Sports Physiol. Perform. (in press).

106. Grassi B., H.B. Rossiter, J.A. Zoladz. Skeletal muscle fatigue and decreased efficiency: two sides of the same coin? Exerc. Sport Science Rev. 43: 75-83, 2015.

107. J.A. Zoladz, B. Grassi. Training: functional improvements of skeletal muscle oxidative metabolism can occur earlier than the enhancement of mitochondrial biogenesis. Exp. Physiol. 100: 1229-1230, 2015.

108. Tam E., P. Bruseghini, E. Calabria, L. Dal Sacco, C. Doria, B. Grassi, T. Pietrangelo, S. Pogliaghi, C. Reggiani, D. Salvadego, F. Schena, L. Toniolo, V. Verratti, G. Vernillo, C. Capelli. GOKYO KHUMBU/AMA DABLAN TREK 2012: Effects of physical training and high altitude exposure on oxidative metabolism, muscle composition and metabolic cost of walking in women. Eur. J. Appl. Physiol. 116: 129-144, 2016.

109. Pišot R., U. Marusic, G. Biolo, S. Mazzucco, S. Lazzer, B. Grassi, C. Reggiani, L. Toniolo, P.E. di Prampero, A. Passaro, M. Narici, S. Mohammed, J. Rittweger, M. Gasparini, M. Gabrijelčič Blenkuš, B. Šimunič. Greater loss in muscle mass and function but smaller metabolic alterations in older compared to younger men following two weeks of bed rest and recovery. J. Appl. Physiol. 120: 922-929, 2016.

110. LoMauro A., A. Cesareo, F. Agosti, G. Tringali, D. Salvadego, B. Grassi, A. Sartorio, A. Aliverti. Effects of a multidisciplinary body weight reduction program on static and dynamic thoraco-abdominal volumes in obese adolescents. Appl. Physiol. Nutr. Metab. 41: 649-658, 2016.

111. Zoladz J.A., J. Majerczak, B. Grassi, Z. Szkutnik, M. Korostyński, M. Grandys, W. Jarmuszkiewicz, W. Kilarski, J. Karasiński, B. Korzeniewski. Mechanisms of attenuation of pulmonary V’O2 slow component in humans after prolonged endurance training. PLoS ONE 11(4): e0154135, 2016.

112. Salvadego D., M.E. Keramidas, L. Brocca, R. Domenis, I. Mavelli, J. Rittweger, O. Eiken, I.B. Mekjavic, B. Grassi. Separate and combined effects of a 10-d exposure to hypoxia and inactivity on oxidative function in vivo and mitochondrial respiration ex vivo in humans. J. Appl. Physiol. 121: 154-163, 2016.

113. Grassi B., V. Quaresima. Near-infrared spectroscopy and skeletal muscle oxidative function in vivo in health and disease: a review from an exercise physiology perspective. J. Biomed. Optics 21 (9), 091313, 2016.

114. Porcelli S., M. Marzorati, L. Morandi, B. Grassi. Home-based aerobic exercise training improves skeletal muscle oxidative metabolism in patients with metabolic myopathies. J. Appl. Physiol. 121: 699-708, 2016.

115. Biolo G., R. Pišot, S. Mazzucco, F.G. Di Girolamo, R. Situlin, S. Lazzer, B. Grassi, C. Reggiani, A. Passaro, J. Rittweger, M. Gasparini, B. Šimunič, M. Narici. Anabolic resistance assessed by oral stable isotope ingestion following bed rest in young and older adult volunteers: relationship with changes in muscle mass. Clin. Nutr. 36: 1420-1426, 2017.

116. Sechi A., D. Salvadego, A. Da Ponte, N. Bertin, A. Dardis, S. Cattarossi, G. Devigili, F. Reccardini, B. Bembi, B. Grassi. Investigation on acute effects of enzyme replacement therapy and influence of clinical severity on physiological variables related to exercise tolerance in patients with Late Onset Pompe Disease. Neuromus. Dis. 27: 542-549, 2017.

117. Grassi B., J. Majerczak, E. Bardi, A. Buso, M. Comelli, S. Chlopicki, M. Guzik, I. Mavelli, Z. Nieckarz, D. Salvadego, U. Tyrankiewicz,T. Skórka, R. Bottinelli, J.A. Zoladz, M.A. Pellegrino. Exercise training in Tgaq*44 mice during the progression of chronic heart failure: cardiac vs. peripheral (soleus muscle) impairments to oxidative metabolism. J. Appl. Physiol. 123: 326-336, 2017.

118. Salvadego D., A. Sartorio, F. Agosti, G. Tringali, A. Patrizi, M. Isola, A. Lo Mauro, A. Aliverti, B. Grassi. Respiratory muscle endurance training reduces the O2 cost of cycling and perceived exertion in obese adolescents. Am. J. Physiol. Reg. Int. Comp. Physiol. 313: R487-R495, 2017.

119. Salvadego D., M.E. Keramidas, R. Kölegård, L. Brocca, S. Lazzer, I. Mavelli, J. Rittweger, O. Eiken, I.B. Mekjavic, B. Grassi. PlanHab*: hypoxia does not worsen the impairment of skeletal muscle oxidative function induced by bed rest alone. J. Physiol. 596: 3341-3355, 2018.

120. Zuccarelli L., S. Porcelli, L. Rasica, M. Marzorati, B. Grassi. Comparisons between slow components of HR and V’O2 kinetics: functional significance. Med. Sci. Sports Exerc. 50: 1649-1657, 2018.

121. Grassi B. Bed rest studies as analogs of conditions encountered in space and diseases. Med. Sci. Sports Exerc. 50: 1907-1908, 2018.

122. Rasica L., S. Porcelli, M. Marzorati, D. Salvadego, A. Vezzoli, F. Agosti, A. De Col., G. Tringali. A.M. Jones, A. Sartorio, B. Grassi. Ergogenic effects of beetroot juice supplementation during severe-intensity exercise in obese adolescents. Am. J. Physiol. Reg. Int. Comp. Physiol. 35: R453-R460, 2018.

123. Alemayehu H.K., D. Salvadego, M. Isola, G. Tringali, M. De Micheli, M. Caccavale, A. Sartorio, B. Grassi. Three weeks of respiratory muscle endurance training improve the O2 cost of walking and exercise tolerance in obese adolescents. Physiol. Rep. 6 (19), e13888, 2018.

124. Grassi B. New data and well-established concepts. J. Appl. Physiol. 125: 1354-1355, 2018 (Letter to the Editor).

125. Marusic U., W. Taube, S.A. Morrison, L. Biasutti, B. Grassi, K. De Pauw, R. Meeusen, R. Pišot, J. Ruffieux. Aging effects on prefrontal cortex oxygenation in a posture-cognition dual-task: an fNIRS pilot study. Eur. Rev. Aging Physical Activity 16: 2, 2019.

126. A. Buso, M. Comelli, R. Picco, M. Isola, B. Magnesa, R. Pišot, J. Rittweger, D. Salvadego, B. Šimunič, B. Grassi, I. Mavelli. Mitochondrial adaptations in elderly and young men skeletal muscle following 2 weeks of bed rest and rehabilitation. Front. Physiol. (Striated Muscle Physiol.). 10: 474, 2019.

127. do Nascimento Salvador P.C., Schäfer L., Grassi B., Antonacci Guglielmo L.G., Denadai B. Changes in V’O2 kinetics after elevated baseline do not necessarily reflect alterations in muscle force production in both sexes. Front. Physiol. (Integr. Physiol.) 10: 471, 2019.

128. Giovanelli N., L. Biasutti, D. Salvadego, H.K. Alemayehu, B. Grassi, S. Lazzer. Changes in skeletal muscle oxidative capacity after a trail running race. Int. J. Sports Physiol. Perform. Jun 12: 1-22, 2019.

129. Porcelli S., B. Grassi, D.C. Poole, M. Marzorati. Exercise intolerance in patients with metabolic myopathies: perfusive and diffusive limitations in the O2 pathway. Current Opinion Physiol. 10: 202-209, 2019.

130. Grassi B., S. Porcelli, M. Marzorati. Translational medicine: exercise physiology applied to metabolic myopathies. Med. Sci. Sports Exerc. 51: 2183-2192, 2019.

131. Bardi E., J. Majerczak, J.A. Zoladz, U. Tyrankiewicz, T. Skorka, S. Chlopicki, M. Jablonska, A. Bar, K. Jasinski,A. Buso, D. Salvadego, Z. Nieckarz, B. Grassi, R. Bottinelli, M.A. Pellegrino. Voluntary physical activity counteracts chronic heart failure progression affecting both cardiac function and skeletal muscle in the transgenic Tgaq*44 mouse model. Physiol. Rep. 7 (13): e14161, 2019.

132. Zuccarelli L., P.C. Do Nascimento Salvador, A. Del Torto, R. Fiorentino, B. Grassi. Skeletal muscle V’O2 kinetics by the NIRS repeated occlusions method during the recovery from cycle ergometry exercise. J. Appl. Physiol. 128: 534-540, 2020.

133. Grassi B., S. Porcelli, M. Marzorati. Metabolic myopathies: “human knockout” models and translational medicine. Front. Physiol. 11: 350, 2020.

134. Porcelli S., L. Rasica, B.S. Ferguson, A.N. Kavazis, J. McDonald, M.C. Hogan, B. Grassi, L.B. Gladden. Effect of acute nitrite infusion on contractile economy and metabolism in isolated skeletal muscle in situ during hypoxia. J. Physiol. 598: 2371-2384, 2020.

135. Zoladz J.A., B. Grassi. A “fatigue threshold” during incremental exercise was identified (and then forgotten) 100 years ago. J. Physiol. 598: 2531-2532, 2020.

136.Narici M., G. De Vito, M. Franchi, A. Paoli, T. Moro, G. Marcolin, B. Grassi, G. Baldassarre, L. Zuccarelli, G. Biolo, F.G. di Girolamo, N. Fiotti, F. Dela, P. Greenhaff, C. Maganaris. Impact of sedentarism due to the COVID-19 home confinement on neuromuscular, cardiovascular and metabolic health: Physiological and pathophysiological implications and recommendations for physical and nutritional countermeasures. Eur. J. Sport Sci. https://doi.org/10.1080/17461391.2020.1761076, 2020.

137. Vaccari F., A. Passaro, A. D’Amuri, J.M. Sainz, F. Di Vece, E. Capatti, B. Magnesa, M. Comelli, I. Mavelli, B. Grassi, F. Fiori, G. Bravo, A. Avancini, M. Parpinel, S. Lazzer. Effects of 3-month high intensity interval training vs. moderate endurance training and 4-month follow-up on fat metabolism, cardiorespiratory function and mitochondrial respiration in obese adults. Eur. J. Appl. Physiol. 120: 1787-1803, 2020.

138. Sechi A., L. Zuccarelli, B. Grassi, R. Frangiamore, R. De Amicis, M. Marzorati, S. Porcelli, A. Tullio, A. Bacco, S. Bertoli, A. Dardis, L. Biasutti, M.B. Pasanisi, G. Devigili, B. Bembi. Exercise training alone or in combination with high protein diet in patients with late onset Pompe disease: results of a cross over study. Orphanet J Rare Dis 15: 143, 2020. https://doi.org/10.1186/s13023-020-01416-6.

139. Zuccarelli L., A. Sartorio, R. De Micheli, G. Tringali, B. Grassi. Obese patients decrease work rate in order to keep a constant target heart rate. Med. Sci. Sports Exerc. 53: 986-993, 2021.

140. Alemayehu H.K., D. Salvadego, G. Tringali, R. De Micheli, M. Caccavale, A. Sartorio, B. Grassi. Acute respiratory muscle unloading improves time-to-exhaustion during moderate- and heavy-intensity cycling in obese adolescent males. Sci. Rep. Oct 12; 10 (1): 17036, 2020. doi: 10.138/s41598-020-74240-4.

141. Grassi B., M.C. Hogan, L.B. Gladden. Microvascular O2 delivery and O2 utilization during metabolic transitions in skeletal muscle. Comp. Biochem. Physiol. Part A 252, 110842, 2021.

142. Do Nascimento Salvador P.C., R.D. de Lucas, L. Schäfer, L.G. Antonacci Guglielmo, B. Grassi, B.S. Denadai. Modeling the depletion and reconstitution of W’: effects of prior exercise on cycling tolerance. Respir. Physiol. Neurobiol. 285: 103590, 2021. https://doi.org/10.1016/j.resp.2020.103590.

143.Zuccarelli L., G. Baldassarre, B. Magnesa, C. Degano, M. Comelli, M. Gasparini, G. Manferdelli, M. Marzorati, I. Mavelli, A. Pilotto, S. Porcelli, L. Rasica, B. Šimunič, R. Pišot, M. Narici, B. Grassi..Peripheral impairments of oxidative metabolism after a 10-day bed rest are upstream of mitochondrial respiration. J. Physiol. 599: 4813-4829, 2021.

144. Salvadego D., B. Grassi, M. Keramidas, O. Eiken, A. McDonnell, I. Mekjavic. Heterogeneity of human adaptations to bed rest and hypoxia: a retrospective analysis within the skeletal muscle oxidative function. Am. J. Physiol. Reg. Int. Comp. Physiol. 321: R813-R822, 2021.

145. Grassi B., V. Quaresima. Mathematical modelling vs. experimental data: how to interpret conflicting evidence? J. Appl. Physiol. 132: 220-221, 2022 (Letter to the Editor).

146. Baldassarre G., L. Zuccarelli, G. Manferdelli, V. Manfredini, M. Marzorati, A. Pilotto, S. Porcelli, L. Rasica, B. Šimunič, R. Pišot, M. Narici, B.  Grassi. Decrease in work rate in order to keep a constant heart rate: biomarker of exercise intolerance following a 10-day bed rest. J. Appl. Physiol. 132: 1569-1579, 2022.

147. D’Amuri A., J.M. Sanz, S. Lazzer, R. Pišot, B. Šimunič, G. Biolo, G. Zuliani, M. Gasparini, M. Narici, B. Grassi, C. Reggiani, E. Dalla Nora, A. Passaro. Irisin attenuates muscle impairment during bed rest through muscle-adipose tissue crosstalk. Biology (Basel): 11 (7): 999, 2022.

148.Graziano E., M. Peghin, M. De Martino, C. De Carlo, A. Da Porto, L. Bulfone, V. Casarsa, E. Sozio, M. Fabris, A. Cifù, B. Grassi, F. Curcio, M. Isola, L.A. Sechi, C. Tascini for the GIRA-COVID study group. The impact of body composition on mortality of COVID-19 hospitalized patients: a prospective study on abdominal fat, obesity paradox and sarcopenia. Clinical Nutrition ESPEN 51: 437-444, 2022.

149.Pilotto A.M., A. Adami, R. Mazzolari, L. Brocca, E. Crea, L. Zuccarelli,M.A. Pellegrino, R. Bottinelli, B. Grassi, H.B. Rossiter, S. Porcelli.Near-infrared spectroscopy estimation of combined skeletal muscle oxidative capacity and O2 diffusion capacity in humans. J. Physiol. 600: 4153-4168, 2022.

150.SturmG., K.R. Karan, A. Monzel, B.S. Santhanam, T. Taivassalo, C. Bris, S.A. Ware, M. Cross, A. Towheed, A. Higgins-Chen, M.J. McManus, A. Cardenas, J. Lin, E.S. Epel, S. Rahman, J. Vissing, B. Grassi, M. Levine, S. Horvath, R.G. Haller, G. Lenaers, D.C. Wallace, M.-P. St-Onge, S. Tavazoie, V. Procaccio, B.A. Kaufman, E.L. Seifert, M. Hirano, M. Picard.OxPhos defects cause hypermetabolism and reduce lifespan in cells and in patients with mitochondrial diseases. Communications Biology 6: 22, 2023.https://doi.org/10.1038/s42003-022-04303-x.

151. Weber T., K. Harris, R. Arya, A. Elias, D.C. Green, D. Greaves, L. Petersen, L. Roberts, T. Kamine, L. Mazzolai, A. Bergauer, D. Kim, R.O. Engberink, P. zu Eulenburg, B. Grassi, L. Zuccarelli, G. Baldassarre, K. Tabury, S. Baatout, J. Jordan, A. Blaber, A. Choukér, T. Russomano, N. Goswami. Pathophysiology, Risk, Diagnosis, and Management of Venous Thrombosis in Space: Where are we now? npj Microgravity (accepted for publication).

 

B)  CHAPTERS IN BOOKS

 

    1. Cerretelli P., M. Meyer, B. Grassi, M. Rieu, C. Cabrol, C. Marconi. Heart transplantation: gas exchange and cardiovascular readjustments. In: B. Carù, E. Tramarin (Eds.). New Trends in Cardiac Rehabilitation. Quaderni di Medicina del Lavoro e Medicina Riabilitativa, Fondazione Clinica del Lavoro, IRCCS, 1992 (p. 68-79).

    2. Grassi B., B. Kayser, P. Cerretelli. Anaerobic metabolism at altitude: recent developments and preliminary results of the Ev-K2-CNR expeditions. Proceedings I Ev-K2-CNR Scientific Conference: Scientific and Technologic Research at High Altitude and Cold Regions. Milano, 1992 (p. 261-269).

    3. Grassi B. Allenamento alla forza e metabolismo aerobico. In: C.U.S.I. Aggiornamenti su Metodiche di Allenamento Sportivo. Uniongrafica Corcelli, Bari, Italy, 1993 (p. 71-96).

    4. Cerretelli P., L. Xi, F. Schena, C. Marconi, B. Grassi, G. Ferretti, M. Meyer. Ventilatory response at the onset of exercise. An update of the neurohumoral theory. In: P.G. Data, H. Acker, S. Lahiri (Eds.). Neurobiology an Cell Physiology of Chemoreception. Plenum Press, New York (p. 327-332), 1993.

    5. Grassi B., G. Ferretti, M. Costa, C. Marconi, P. Cerretelli. Chemoreflexogenic ventilatory drive in humans adapted to unusual environments. In: P.G. Data, H. Acker, S. Lahiri (Eds.). Neurobiology an Cell Physiology of Chemoreception. Plenum Press, New York (p. 353-357), 1993.

    6. Cerretelli P., B. Grassi, B. Kayser. Anaerobic metabolism at altitude: recent developments. In: F. León-Velarde and A. Arregui (Eds.). Hipoxia: Investigaciones bàsicas y Clìnicas. IFEA - UPCH, Lima, Peru (p. 167-179), 1993.

    7. Grassi B., P. Cerretelli. Exercise at high altitude: maximal aerobic power and maximal lactic capacity. In: R. Baudo, G. Tartari, M. Munawar (Eds.). Top of the world environmental research: Mount Everest - Himalayan ecosystem. Backhuys Publishers, Leiden, The Netherlands (p. 253-262), 1998.

    8. Cerretelli P., B. Grassi, C. Marconi. Changes in aerobic and anaerobic metabolism in the elderly. In: P. Capodaglio, M.V. Narici (Eds). Advances in Rehabilitation, Maugeri Foundation Books, Vol. 1, No. 2, Pavia, Italy (p. 77-87)., 1999.

    9. Meyer M., C. Marconi, A. Rahmel, B. Grassi, G. Ferretti, J.E. Skinner, P. Cerretelli. Fractal dynamics of heartbeat interval fluctuations in health and disease. In: F. Orsucci (Ed.). The Complex Matters of Mind. “Nonlinear Phenomena in Life Science”, vol. 6. World Scientific Publishing, Singapore (p. 105-128), 1999.

    10. Meyer M., C. Marconi, A. Rahmel, B. Grassi, G. Ferretti, J.E. Skinner, P. Cerretelli. Fractal dynamics of heartbeat interval fluctuations. In: Chaos Fractal Models. F.M. Guindani, G. Salvadori (Eds.). Italian University Press, Rome (p. 75-83), 1999.

    11. Grassi B. Immersione subacquea. In: L’Universo del Corpo, Volume III, pag. 845-849. Istituto dell’Enciclopedia Italiana, Fondata da Giovanni Treccani. Roma, 1999.

    12. Grassi B. Scambi gassosi e metabolismo energetico in alta quota. In: Il Test da Sforzo Cardiopolmonare. Teoria ed Applicazioni. P. Palange, F. Schena (Eds.). COSMED srl, Rome (p. 47-59), 2001.

    13. Grassi B. Limitation of skeletal muscle V’O2 on-kinetics by inertia of cellular respiration. In: A.M. Jones & D.C. Poole (Eds.): Oxygen Uptake Kinetics in Sport, Exercise and Medicine. Routledge, London, UK , 2004 (p. 212-229).

    14. Grassi B. O2 uptake kinetics in skeletal muscle: why is it so slow? And what does it mean? Adv. Exp. Med. Biol. 578: 17-22, 2006.

    15. P.E. di Prampero, B. Grassi. Capitolo 86. Energetica della contrazione muscolare. In: F. Baldissera & C.A. Porro (Eds.). Fisiologia e Biofisica Medica. IV edizione. Poletto Editore, Vermezzo (MI), Italy, 2009 (p. 1185-1193).

    16. P.E. di Prampero, B. Grassi. Capitolo 87. Lavoro muscolare. In: F. Baldissera & C.A. Porro (Eds.). Fisiologia e Biofisica Medica. IV edizione. Poletto Editore, Vermezzo (MI), Italy, 2009 (p. 1194-1219).

    17. P.E. di Prampero, B. Grassi. Capitolo 88. Metabolismo energetico. In: F. Baldissera & C.A. Porro (Eds.). Fisiologia e Biofisica Medica. IV edizione. Poletto Editore, Vermezzo (MI), Italy, 2009 (p. 1220-1236).

    18. P.E. di Prampero, B. Grassi. Capitolo 89. Energetica della locomozione. In: F. Baldissera & C.A. Porro (Eds.). Fisiologia e Biofisica Medica. IV edizione. Poletto Editore, Vermezzo (MI), Italy, 2009 (p. 1237-1248).

    19. Grassi B., J. A. Zoladz. Zintegrowana odpowiedź ustroju na niedotlenienie wysokościowe. In: J. Górski (Ed.). Fizjologia wysiłku i treningu fizycznego. Wydawnictwo Lekarskie PZWL, Warszawa, Poland, 2011 (p. 183- 197).

    20. Zoladz J. A, B. Grassi. Training: Maximal Oxygen Uptake (V’O2max). In: Encyclopedia of Exercise Medicine in Health and Disease. Springer-Verlag, Berlin Heidelberg, Germany. (in press).

    21. Grassi B. Capitolo 79 - Bioenergetica del muscolo scheletrico. In: F. Grassi, D. Negrini, C.A. Porro (Eds.). Fisiologia Medica. Poletto Editore, Vermezzo (I), 2015 (pag. 865-884).

    22. Grassi B. Capitolo 80 - Adeguamenti respiratori, cardiovascolari e metabolici all’esercizio. In: F. Grassi, D. Negrini, C.A. Porro (Eds.). Fisiologia Medica. Poletto Editore, Vermezzo (I), 2015 (pag. 885-891).

    23. Grassi B. Capitolo 81 - Termoregolazione durante esercizio. In: F. Grassi, D. Negrini, C.A. Porro (Eds.). Fisiologia Medica. Poletto Editore, Vermezzo (I), 2015 (pag. 892-895).

    24. Grassi B. Capitolo 82 - Risposte fisiologiche a condizioni ambientali particolari: ipossia e microgravità. In: F. Grassi, D. Negrini, C.A. Porro (Eds.). Fisiologia Medica. Poletto Editore, Vermezzo (I), 2015 (p. 896-900).

    25. Grassi B. Capitolo 83- Esercizio fisico nell’anziano ed in condizioni patologiche. In: F. Grassi, D. Negrini, C.A. Porro (Eds.). Fisiologia Medica. Poletto Editore, Vermezzo (I), 2015 (p. 901-903).

    26. Zoladz J.A., Z. Szkutnik, B. Grassi. Chapter 18. Metablic Transitions and Muscle Metabolic Stability: Effects of Exercise Training. In: Zoladz J.A. (Ed.). Muscle and Exercise Physiology. Academic Press – Elsevier, 2019 (p. 391-422).

    27. Grassi B. Sezione 13. Fisiologia Integrativa dell’Esercizio Fisico – Introduzione. In: F. Grassi, D. Negrini, C.A. Porro, P. Borroni, G. Cerri, M. Zoli. Fisiologia Umana. Seconda Edizione. Poletto Editore, Vermezzo (I), 2022 (p. 908).

    28. Grassi B. Capitolo 82 – Bioenergetica del muscolo scheletrico. In: F. Grassi, D. Negrini, C.A. Porro, P. Borroni, G. Cerri, M. Zoli. Fisiologia Umana. Seconda Edizione. Poletto Editore, Vermezzo (I), 2022 (p. 909-928).

    29. Grassi B. Capitolo 83 – Adeguamenti respiratori, cardiovascolari e metabolici all’esercizio. In: F. Grassi, D. Negrini, C.A. Porro, P. Borroni, G. Cerri, M. Zoli. Fisiologia Umana. Seconda Edizione. Poletto Editore, Vermezzo (I), 2022 (p. 929-935).

    30. Grassi B. Capitolo 84 – Termoregolazione durante esercizio. In: F. Grassi, D. Negrini, C.A. Porro, P. Borroni, G. Cerri, M. Zoli. Fisiologia Umana. Seconda Edizione. Poletto Editore, Vermezzo (I), 2022 (p. 936-939).

    31. Grassi B. Capitolo 85 – Risposte fisiologiche a condizioni ambientali particolari: ipossia e microgravità. In: F. Grassi, D. Negrini, C.A. Porro, P. Borroni, G. Cerri, M. Zoli. Fisiologia Umana. Seconda Edizione. Poletto Editore, Vermezzo (I), 2022 (p. 940-944).

    32. Grassi B. Capitolo 86 – Esercizio fisico in condizioni patologiche. In: F. Grassi, D. Negrini, C.A. Porro, P. Borroni, G. Cerri, M. Zoli. Fisiologia Umana. Seconda Edizione. Poletto Editore, Vermezzo (I), 2022 (p. 945-948).

 

C) INVITED LECTURES

 

    1. Grassi B., C. Marconi, P. Cerretelli. Facteurs limitant la performace chez le sujects du troisieme age. Congress "Exercise et vieillissement". Saint Etienne (F), June 9-10, 1989.

    2. Grassi B., C. Marconi, P. Cerretelli. Fattori limitanti l'attività prestativa nella terza età. National Congress of the "Associazione Nazionale Specialisti in Medicina dello Sport dell'Università di Chieti". Chieti (I), July 9-12, 1989.

    3. Grassi B. Scambi gassosi e metabolismo energetico durante apnee profonde. "I Corso Internazionale di Medicina del Mare". Siracusa (I), July 24-29, 1989.

    4. Grassi B., B. Kayser, M. Marzorati, M. Bordini, C. Marconi, P. Cerretelli. Anaerobic metabolism at high altitude. 1st Ev- K2-CNR Scientific Conference. Milan (I), Apr. 10-11, 1992.

    5. Grassi B., C. Marconi, P. Cerretelli. L'atleta veterano: basi fisiologiche della prestazione sportiva. Congress "La Medicina dello Sport alle soglie del XXI secolo". Iesi, AN (I), Oct. 23-24, 1992.

    6. Grassi B. Scambi gassosi e metabolismo energetico durante esercizio in alta quota. Congress of the “Società Italiana di Medicina Respiratoria”. Belgirate, NO (I), Apr. 21-23, 1994.

    7. Grassi B., G. Ferretti, M. Costa, C. Marconi, P. Cerretelli. L’immersione profonda in apnea. Conference “La Medicina dello Sport verso il 2000. I limiti della prestazione fisica”. Como (I), May 27-28, 1994.

    8. Grassi B. Metabolismo anaerobico in alta quota. International Meeting: "L'uomo e l'ambiente montano estremo". Castel Ivano, TN (I). Nov. 4-5, 1994.

    9. Grassi B. Fattori limitanti l'esercizio fisico in alta quota. Congress "Valutazione degli Atleti e dei Materiali negli Sport Invernali." E.C.U.S. Rovereto, TN (I), November 4, 1995.

    10. Grassi B. Il metabolismo energetico anaerobico in alta quota. XII National Congress "Associazione Italiana di Dietetica e Nutrizione Clinica". Torino (I), November 16-18, 1995.

    11. Grassi B. Aerobic and anaerobic energetic metabolism in hypoxia. International Advanced Course in Cardiovascular Physiology and Pathophysiology Applied to Physical Exercise and Sport. Scuola dello Sport, C.O.N.I.. Rome (I), November 28, 1995.

    12. Grassi B. La prestazione muscolare in alta quota. Convegno di Cardiologia dello Sport. Varese (I), February 10, 1996.

    13. Grassi B. Nutrition and exercise at high altitude. XVIII Congress of the European Society of Parenteral and Enteral Nutrition. Geneva (CH), September 8-11, 1996.

    14. Grassi B. Applicazione della spettroscopia nel vicino infrarosso alla fisiologia dell’esercizio. Conference “Valutazione non-invasiva della prestazione muscolare”. L’Aquila (I), May 6, 1997.

    15. Grassi B. Anaerobic and lactic metabolism in chronic hypoxia. XXXIII Congress of the International Union of Physiological Sciences. St. Petersburg (Russia), June 30 - July 5, 1997.

    16. Grassi B. Non-invasive evaluation of oxidative metabolism in skeletal muscle by NIRS. The “lactate”, or “ventilatory”, or “anaerobic” threshold. Workshop “Recent advances and further developments of near infrared optical methods for non invasive tissue monitoring in medicine. Sapporo (JPN), February 25-27, 1998,

    17. Grassi B. V’O2 on-kinetics: set by blood flow or muscle metabolism? Symposium: “Skeletal muscle: master or slave of the cardiovascular system?”45th Annual Meeting of the American College of Sports Medicine. Orlando, Florida (USA), June 3-6, 1998.

    18. Grassi B. V’O2 on-kinetics. The case against O2 supply limitation. Symposium “Skeletal muscle V’O2 on-kinetics”. 46th Annual Meeting of the American College of Sports Medicine. Seattle, Washington (USA), June 2-5, 1999.

    19. Grassi B. Exercise transients. Satellite Course “Integrative muscle physiology: from cross-bridges to whole muscle performance and environmental adaptations”. 4th Congress of the European College of Sport Science. Rome (I), July 13-14, 1999.

    20. Grassi B. Cardiovascular and gas exchange kinetics in heart transplant recipients. Symposium “Skeletal muscle: dysfunction or disuse in cardiopulmonary disease?”. 47th Annual Meeting of the American College of Sports Medicine. Indianapolis, Indiana (USA), May 31 - June 3, 2000.

    21. Grassi B. Tutorial Lecture: “Assessment and physiological significance of V’O2 kinetics.” 47th Annual Meeting of the American College of Sports Medicine. Indianapolis, Indiana (USA), May 31 - June 3, 2000.

    22. Grassi B. NIRS and exercise physiology: hopes and reality. Clinical Exercise Physiology Meeting. British Association of Sport and Exercise Sciences. Manchester (UK), November 1, 2000.

    23. Grassi B. V’O2 kinetics across exercising muscles: inferences on metabolic control. Symposium: Kinetics of oxygen uptake. 6th Annual Congress of the European College of Sport Science. Cologne (D), July 24-28, 2001.

    24. Grassi B., L. Morandi, S. Pogliaghi, S. Rampichini, C. Marconi, P. Cerretelli. Functional evaluation of metabolic myopathies during exercise: a role for NIRS? Workshop “Non Invasive Investigation of Muscle Function”. Marseille (F), October 4-6, 2001.

    25. Grassi B. Acid-base equilibrium at intermediate and high altitude. AlpenForum 2002. Alpbach (A), September 23-27, 2002.

    26. Grassi B. Fisiologia degli scambi gassosi. II Corso Annuale AIPO di Fisiopatologia Respiratoria: Scambi Gassosi e Diffusione. Roma, November 28-30, 2002.

    27. Grassi B. Oxygen uptake kinetics: old and recent lessons from experiments on isolated muscle in situ. “Integrative Physiology: Facts and Theories”, Symposium in honour of Professor Paolo Cerretelli on the occasion of his seventieth birthday. Udine, November 27-29, 2003.

    28. Grassi B. Basi fisiologiche dell’esercizio. III Corso Annuale AIPO di Fisiopatologia Respiratoria: Test da Sforzo Cardiopolmonare. Roma, December 1-3, 2003.

    29. Grassi B. Valutazione ergo-spirometrica: metodologie e tecniche. Corso Nazionale Società Italiana Cardiologia dello Sport: “Ergometria e Sport – Aspetti elettrocardiografici, ecocardiografici, scintigrafici, spiroergometrici”. Mantova (I), April 23-24, 2004.

    30. Grassi B. Dal muscolo isolato all’organismo dell’uomo: cinetica degli scambi gassosi. 8° Congresso Nazionale di Medicina dello Sport: “Conoscere lo Sport”. Firenze (I), May 9-11, 2004.

    31. Grassi B. Oxygen uptake kinetics in skeletal muscle. Symposium “The oxygen uptake dynamics: from muscle to mouth”. 51st Annual Meeting, American College of Sports Medicine; Indianapolis (IN), USA; June 2-5, 2004.

    32. Grassi B. Oxygen uptake kinetics: Why is it so slow? And what does it mean? 32nd Annual Conference, International Society of Oxygen Transport to Tissues (ISOTT). Bari (I), August 21-26, 2004.

    33. Grassi B. Scambi gassosi a riposo e durante esercizio. IV Corso Annuale AIPO. Corso Avanzato di Fisiopatologia Respiratoria. Roma; December 13-15, 2004.

    34. Grassi B. Central and peripheral limitations to oxidative metabolism in aging. Symposium: Aging, physical activity and health. 10th Annual Congress, European College of Sport Science. Belgrade, Serbia; July 13-16, 2005.

    35. Grassi B. Skeletal muscle oxidative metabolism and exercise tolerance. Satellite Symposium: Determinants of physical frailty and adaptations to exercise in old age: overview of the Better Ageing project – a multi-centre study in older european citizens. 10th Annual Congress, European College of Sport Science. Belgrade, Serbia; July 13-16, 2005.

    36. Grassi B. Limitazioni del metabolismo energetico ossidativo. II Corso Annuale Pneumologico dell’Ospedale San Martino: L’esercizio fisico in condizioni normali e patologiche. Genova (I); October 13-14, 2005.

    37. Grassi B. Limitazioni centrali e periferiche del metabolismo energetico ossidativo. Convegno: “Sport agonistico: sacrificio o stile di vita”. Milano (I); October 14, 2005.

    38. Grassi B. VO2 kinetics: old and recent lessons from experiments on isolated muscle in situ. 11th Annual Congress. European College of Sport Science. Lausanne (CH); July 5-8, 2006.

    39. Grassi B. Oxygen uptake kinetics: Why is it so slow? And what does it tell us? Session: Adaptive responses of muscle metabolism to exercise. XXIII Congress of the Polish Physiological Society. “Physiology without limits”. Warsaw (PL); September 15-16, 2006.

    40. Grassi B. Functional evaluation of oxidative metabolism in patients with metabolic myopathies. Symposium: Skeletal muscle function: length dependent and metabolic aspects. Institute for Fundamental and Clinical Human Movement Sciences, Vrije Universiteit, Amsterdam (NL); March 16, 2007.

    41. Grassi B. Functional evaluation of oxidative metabolism in patients with metabolic myopathies. Symposium: Maintaining mobility in health, disease and old age. 12th Annual Congress. European College of Sport Science. Jyväskylä (SF); July 11-14, 2007.

    42. Grassi B. Near-infrared Spectroscopy. European Respiratory Society Research Seminar, “The limit to exercise in COPD: new insights from new methods”. Como (I), September 27-28, 2007.

    43. Grassi B. V’O2 slow component: lessons from animal models. Symposium “The slow component of V’O2 kinetics: mechanistic bases and practical applications”. 2010 Annual Meeting, American College of Sports Medicine. Baltimore, Maryland (USA); June 2-5, 2010.

    44. Grassi B. Energetics of muscular exercise : influence of Margaria on recent advances in the field.Symposium “Evolution and recent advances of exercise physiology in Italy”. 61° Congresso Nazionale, Società Italiana di Fisiologia. Varese (I): September 15-17, 2010.

    45. Grassi B. Exercise bioenergetics: what we learn from metabolic transitions. Symposium: “Exercise physiology and the limits of human performance. A tribute to Prof. Pietro Enrico di Prampero”. Gemona del Friuli, UD (I): October 7-8, 2010.

    46. Grassi B. Enhancement in sports. XV International Intensive Course in Bioethics. Expressing Ethics & Human Values in Innovative Health Care. University of Udine. Udine, July 11-22, 2011.

    47. Grassi B. Pathophysiology of chronic heart failure: insights from oxygen uptake kinetics. 2nd Training course on the use of cardiopulmonary exercise testing in cardiology. Fondazione S. Maugeri, IRCSS – Scientific Institute of Veruno. Veruno, NO (I): November 9-10, 2012.

    48. Grassi B. Pulmonary gas exchange during constant work rate exercise: inferences on performance. 17th FINA World Sports Medicine Congress. Istanbul (Turkey); December 10-11, 2012.

    49. Grassi B. Hypoxic training and exercise performance. 17th FINA World Sports Medicine Congress. Istanbul (Turkey); December 10-11, 2012.

    50. Grassi B. Skeletal muscle oxidative metabolism in vivo and in vitro following muscle atrophy and hypertrophy. 60th Annual Meeting, American College of Sports Medicine. Indianapolis, Indiana (USA); May 28-June 1, 2013.

    51. Grassi B. Oxygen uptake kinetics and muscle fatigue in an isolated muscle model. 60th Annual Meeting, American College of Sports Medicine. Indianapolis, Indiana (USA); May 28-June 1, 2013.

    52. Grassi B. Skeletal muscle fatigue and decreased efficiency of contractions. 26th Congress of the Polish Physiological Society. Szczecin (Poland); September 18-20, 2014.

    53. Grassi B. Applied physiology of exercise (in)tolerance in patients with metabolic myopathies.Symposium: The Physiology & Pathophysiology of Exercise Intolerance. Los Angeles Biomedical Research Institute; Harbor-UCLA Medical Center. Los Angeles, California (USA): June 1 2015.

    54. Grassi B. Combined effects of inactivity and hypoxia on skeletal muscle oxidative metabolism in humans. Symposium: Cellular and physiological adaptations to physical training and detraining in hypoxia. 66° National Congress, Italian Physiological Society. Genova (I); September 16-18, 2015.

    55. Grassi B. Applied physiology of exercise (in)tolerance in patients with metabolic myopathies. Symposium: Muscle Exercise and Plasticity. 44th European Muscle Conference. Warsaw (Poland); September 21-25, 2015.

    56. Grassi B. Balance/unbalance between O2 consumption and O2 delivery during rest-to-work transitions in skeletal muscle. Symposium: Structural and functional adaptations to physical exercise at the cerebrovascular, cardiovascular and skeletal muscle level. 67° National Congress, Italian Physiological Society. Catania (I); September 21-23, 2016.

    57. Grassi B. Loss of efficiency during constant work rate exercise and exercise (in)tolerance. Symposium: Exercise tolerance: from functional indexes to individualized prescription. 68th National Congress, Italian Physiological Society. Pavia (I); September 6-8, 2017.

    58. Grassi B. NIRS and skeletal muscle in the evaluation of pathological conditions. Symposium: Revisit: NIRS, what can it tell us about muscle for exercise. 65th Annual Meeting, American College of Sports Medicine. Minneapolis, Minnesota (USA); May 29-June 3, 2018.

    59. Grassi B. Tools of functional evaluation of oxidative metabolism along the O2 pathway. Symposium: Is mitochondrial respiration a limiting factor of oxidative metabolism? An ntegrative approach to exercise (in)tolerance. VIII Meeting, Integrative Physiology of Exercise, American College of Sports Medicine. San Diego, California (USA); Sept. 5-9, 2018.

    61. Grassi B. Near-infrared spectroscopy and skeletal muscle oxidative function in vivo in health and disease: an exercise physiology perspective. ART Scientific 2019. Egmond aan Zee (NL); May 9-11, 2019.

    62. Grassi B. Physical activity and the cardiorespiratory system. A matter of survival. Technogym Webinar “Reccommendations for physical and nutritional measures to counteract forced sedentarism. April 10th, 2020.

    63. Grassi B. Near-infrared spectroscopy of skeletal muscle and exercise physiology in health and disease: several limitations, many potential useful information. ARTScientific Webinar Series, November 26th, 2020.

    64. Grassi B. Exercise physiology applied to metabolic myopathies: an example of translational medicine. Centre for Human and Applied Physiological Sciences. King’s College, London, UK. Webinar, April 21st, 2021.

    65. Grassi B. Armi a doppio taglio: l’ossigenoterapia. Basi razionali per un uso non sempre razionale. Corso Pre-congressuale, 122° Congresso Nazionale Società Italiana di Medicina Interna (SIMI): Gestione delle urgenze in Medicina Interna. Rome, Italy, October 21st 2021.

    66. Grassi B., G. Baldassarre, L. Zuccarelli. Peripheral impairments of oxidative metabolism during exercise following inactivity. Symposium: The curse of inactivity. 2022 Padua Days on Muscle & Mobility Medicine. Padua (I): March 30-April 2, 2022.

    67. Grassi B. Acute and chronic adjustments to hypoxia: when does the blanket becomes short? Jagiellonian University, Collegium Medicum. Krakow (PL), November 15, 2022.

    68. Grassi B. Exercise physiology applied to metabolic myopathies: an example of translational medicine. Jagiellonian University, Collegium Medicum. Krakow (PL), November 28, 2022.

 

D) COMMUNICATIONS TO CONGRESSES

 

     1. Marconi C., B. Grassi, B. Carù, P. Cerretelli. Gas exchange transients in heart transplant recipients. Fed. Proc. 46: 677, 1987.

     2. Grassi B., C. Marconi, G.S. Roi, M.V. Narici, A. Colombini, P. Cerretelli. Anaerobic power and isokinetic strength in master athletes. FASEB J. 2: A713, 1988.

     3. Marconi C., B. Grassi, A. Colombini, B. Carù , P. Cerretelli. Pulmonary ventilation and gas exchange in heart transplant recipients. Eur. Resp. J. 1: 119S, 1988.

     4. Cerretelli P., B. Grassi. Limiti della prestazione fisica in età evolutiva. Nat. Congr. of the "Associazione Nazionale Specialisti in Medicina dello Sport dell'Università di Chieti". Chieti, PE (I), July 3-6, 1988.

     5. Binzoni T., G. Ferretti, K. Shenker, F. Beth, B. Grassi, P. Cerretelli. PC kinetics during exercise in a case of mitochondrial enzymatic disease. XL National Congress “Società Italiana di Fisiologia”. Sassari (I), September 26-28, 1988.

     6. Cerretelli P., B. Grassi, G. Ferretti, A. Colombini, M. Rieu, X. Lei, M. Meyer, C. Marconi. Regulation of ventilation at exercise after lung and heart denervation in humans. FASEB J. 3: A855, 1989.

     7. Marconi C., B. Grassi, A. Colombini, B. Carù, P. Cerretelli. Gas exchange and metabolic transients in heart transplant recipients. Pflüg. Archiv 413: S5, 1989.

     8. Grassi B., C. Marconi, G.S. Roi, M.V. Narici, A Colombini, P. Cerretelli. Maximal anaerobic (alactic and lactic) performance in master athletes. Pflüg. Archiv 414: S54, 1989.

     9. Roi G.S., B. Grassi, A. Colombini, P. Buselli, C. Marconi. Energy sources in ski alpinism. Pflüg. Archiv 414: S54, 1989.

     10. Marconi C., B. Grassi, G.S. Roi, M.V. Narici, A. Colombini, P. Cerretelli. Potenza muscolare "picco" in atleti veterani. Giorn. Gerontol. 37: 787, 1989.

     11. Meyer M., C. Marconi, B. Grassi, M. Rieu, P. Cerretelli, C. Cabrol. Adjustments to exercise of cardiovascular function in heart transplant recipients. Intensive Care Med. 15: A409, 1989.

     12. Meyer M., C. Marconi, B. Grassi, M. Rieu, P. Cerretelli, A. Cabrol, C. Cabrol. Dynamics of respiratory and cardiac function in heart transplant recipients during exercise. Physiologist 32: 230, 1989.

     13. Grassi B., C. Marconi, G.S. Roi, M.V. Narici, A. Colombini, P. Cerretelli. Peak muscular power in master athletes. XXXI Int. Congr. of Physiological Sciences. Helsinki (SF), July 9-14, 1989.

     14. Ferretti G., B. Grassi, C. Marconi. G. Atchou, P. Cerretelli. Energetics of locomotion in african pygmoids. XXXI Int. Congr. of Phsiological Sciences. Helsinki (SF), July 9-14, 1989.

     15. Roi G.S., B. Grassi, C. Marconi. Il costo energetico dello sci-alpinismo in salita. Proceedings of the "IV Meeting Nazionale di Medicina dello Sport". Porto San Giorgio, PE (I), Sept. 28-30, 1989 (pp. 176-179).

     16. Grassi B., C. Marconi, and P. Cerretelli. Puissances maximales aerobie et anaerobie chez l'athlete veteran. Int. Congr. "Sport Effort Medecine". Biarritz (F), Sept. 29-30, 1989.

     17. Cerretelli P., M. Costa, G. Ferretti, M. Ferrigno, B. Grassi, C.E.G. Lundgren, C. Marconi (intr. by A.J. Sargeant). Gas exchange and energy metabolism during deep breath-hold diving in elite human divers. J. Physiol. (London) 420: 120P, 1990.

     18. Ferrigno M., M. Costa, G. Ferretti, C. Marconi, B. Grassi, P. Cerretelli, C.E.G. Lundgren. ECG in elite human divers during deep breath-hold dives. Joint Meeting on Diving and Hyperbaric Medicine. Amsterdam (NL), Aug. 11-18, 1990.

     19. Cerretelli P., C. Marconi, B. Grassi, M. Meyer, M. Rieu, C. Cabrol. The efficacy of the Frank-Starling mechanism in the human transplanted heart. Experientia 47: A27, 1991.

     20. Grassi B., G. Ferretti, M. Costa, M. Ferrigno, C.E.G. Lundgren, C. Marconi, P. Cerretelli. Chemoreflexogenic ventilatory drive in humans adapted to unusual environments. Int. Symp. on Arterial Chemoreception, Chieti, PE (I), June 24-28, 1991.

     21. Cerretelli P., L. Xi, F. Schena, C. Marconi, B. Grassi, G. Ferretti, M. Meyer. Ventilatory response at the onset of exercise. An update of the neuro-humoral theory. Int. Symp. on Arterial Chemoreception. Chieti, PE (I), June 24-28, 1991.

     22. Marconi C., B. Grassi, B.E.J. Kayser, T. Binzoni, M. Bordini, P. Cerretelli. Peak lactic capacity during altitude (5050 m) acclimatization and in the deacclimatization phase. Regional Meeting of IUPS. Prague (CZ), June 30-July 5, 1991.

     23. Kayser B.E.J., G. Ferretti, B. Grassi, T. Binzoni, P. Cerretelli. Blood lactate after exhaustive exercise at altitude in humans: influence of bicarbonate loading. Regional Meeting of IUPS. Prague (CZ), June 30-July 5, 1991.

     24. Meyer M., A. Rahmel, G. Hahn, C. Marconi, B. Grassi, M. Rieu, P. Cerretelli, A. Cabrol. Heart rate variability in human cardiac transplant recipients. Regional Meeting of IUPS. Prague (CZ), June 30-July 5, 1991.

     25. Narici M.V., B. Kayser, F. Cibella, B. Grassi, P. Cerretelli. No changes in body composition and maximal alactic anaerobic performance during a 4-week sojourn at altitude. Int. J. Sports Med. 13: 87, 1992.

     26. Kayser B., G. Ferretti, B. Grassi, T. Binzoni, P. Cerretelli. Blood lactate after exhaustive exercise at high altitude in humans: influence of bicarbonate loading. Int. J. Sports Med 13: 88-89, 1992.

     27. Marconi C., M. Meyer, B. Grassi, M. Rieu, A. Cabrol, P. Cerretelli. Gas exchange in a human Jarvik-7 total artificial heart recipient. Pflüg. Arch. 420: R166, 1992.

     28. Grassi B., B.E.J. Kayser, T. Binzoni, M. Marzorati, M. Bordini, C. Marconi, P. Cerretelli. Peak blood lactate concentration during altitude acclimatization and deacclimatization in humans. Pflüg. Arch. 420: R165, 1992.

     29. Cerretelli P., L. Xi, F. Schena, C. Marconi, B. Grassi, G. Ferretti, M. Meyer. Regulation of ventilation at the onset of exercise in humans. Pflüg. Archiv 421: R29, 1992.

     30. Marzorati M., C. Marconi, B. Grassi, M. Bordini, P. Cerretelli. The kinetics of VO2 in master athletes. Pflüg. Archiv 421: R30, 1992.

     31. Marconi C., M. Marzorati, B. Grassi, M. Conti, M. Bordini, P. Cerretelli. Gas exchange kinetics in the elderly. Physiologist 35: 233, 1992.

     32. Grassi B., B. Kayser, M. Marzorati, A. Colombini, C. Marconi, P. Cerretelli. Peak blood lactate concentration and blood buffering capacity during high altitude acclimatization and deacclimatization in humans. Physiologist 35: 211, 1992.

     33. Kayser B., B. Grassi, G. Ferretti, A. Colombini, C. Marconi, P. Cerretelli. Maximal rate of lactate accumulation during high altitude exposure. Physiologist 35: 211, 1992.

     34. Ferretti G., B. Grassi, L. Xi, M. Rieu, M. Meyer, C. Marconi, P. Cerretelli. Exercise ventilation and gas exchange after heart and lung denervation in humans. Physiologist 35: 229, 1992.

     35. Narici M., B. Kayser, T. Binzoni, B. Grassi, M. Bordini, P. Cerretelli. Muscle function at high altitude. 1st Ev-K2-CNR Scientific Conference. Milan (I), Apr. 10-11, 1992.

     36. Kayser B., T. Binzoni, M.V. Narici, B. Grassi, P. Cerretelli. Peripheral fatigue in chronic hypobaric hypoxia: influence of exercising muscle volume. J. Physiol. (London) 467: 62P, 1993.

     37. Kayser B., B. Grassi, G. Ferretti, A. Colombini, C. Marconi, P. Cerretelli. Maximal rate of blood lactate accumulation during high altitude exposure in humans. Experientia 49: A61, 1993.

     38. Binzoni T., B. Kayser, M.V. Narici, B. Grassi, P. Cerretelli. Fatigue in chronic hypobaric hypoxia. Experientia 49: A61, 1993.

     39. Richardson R.S., D.R. Knight, D.C. Poole, S.S. Kurdak, M.C. Hogan, B. Grassi, E.C. Johnson, B.K. Erickson, B. Kennedy, P.D. Wagner. Tissue diffusion limitation of VO2max in the quadriceps of normal man is not affected by hypoxemia. I.S.O.T.T. 21st Annual Meeting. San Diego (USA), Aug. 14-18, 1993.

     40. Podolsky A., M.W. Eldridge, R.S. Richardson, D.R. Knight, E.C. Johnson, S.R. Hopkins, H. Michimata, B. Grassi, J. Feiner, S.S. Kurdak, J.M. Uribe, D.C. Poole, P.E. Bickler, J.W. Severinghaus, P.D. Wagner. Relationship between susceptibility to high altitude pulmonary edema and to exercise induced ventilation-perfusion mismatch. Am. J. Respir. Crit. Care Med. 149: A818, 1994.

     41. Richardson R.S., D.R. Knight, D.C. Poole, S.S. Kurdak, M.C. Hogan, B. Grassi, P.D. Wagner. Hypoxic and normoxic muscle VO2max during single leg knee-extensor exercise in man. Med. Sci. Sports Exerc. 26: S164, 1994.

     42. Knight D.R., B.K. Erickson, R.S. Richardson, D.C. Poole, B. Grassi, J. Struthers, P.D. Wagner. Measurement of transitional blood flow in the leg. Med. Sci. Sports Exerc. 26: S162, 1994.

     43. Kurdak S.S., B. Grassi, M.C. Hogan, P.D. Wagner. Blood flow distribution and muscle O2 diffusion conductance during ischemic and anemic contractions. I.S.O.T.T. 22nd Annual Meeting. Istambul (T), August 22-26, 1994.

     44. Grassi B., P. Mognoni, M. Marzorati, A. Colombini, S. Mattiotti, E. Caspani, C. Marconi, P. Cerretelli. Effect of chronic hypoxia on peak capillary lactate after exhaustive exercises of various duration. FASEB Journal 9: A648, 1995.

     45. Conti M., C. Marconi, B. Grassi, M. Marzorati, P. Cerretelli. Chronic hypoxia (5050 m) does not affect the rate of readjustment of muscle oxidations. FASEB Journal 9: A648, 1995.

     46. Marzorati M., C. Marconi, B. Grassi, A. Colombini, M. Conti, E. Caspani, P. Cerretelli. VO2max in chronic hypoxia: grater reduction in athletes than in sedentary subjects. FASEB Journal 9: A648, 1995.

     47. Marconi C., M. Marzorati, M. Conti, B. Grassi, P. Ferrazzi, R. Fiocchi, P. Cerretelli. Heart transplanted children (HTR-C): is there any evidence for functional cardiac reinnervation? FASEB Journal 9: A8, 1995.

     48. Kurdak S.S., B. Grassi, P.D. Wagner, M.C. Hogan. Effect of [hemoglobin] on blood flow distribution and O2 transport in maximally working skeletal muscle. FASEB Journal 9: A654, 1995.

     49. Poole D.C., B. Grassi, R.S. Richardson, D.R. Knight, B.K. Erickson, P.D. Wagner. Muscle O2 uptake kinetics in humans: dissociation between O2 delivey and uptake. FASEB Journal 9: A359, 1995.

     50. Marconi C., M. Marzorati, M. Conti, B. Grassi, P. Ferrazzi, R. Fiocchi, E. Cohen-Laroque, P. Cerretelli. Heart transplanted children (HTR-C): is there any evidence for functional cardiac reinnervation? Experientia 51: A79, 1995.

     51. Cerretelli P., B. Grassi. High altitude effects on physical performance: laboratory indices. Joint Meeting of Clinical Biochemist. Padova (I), June 1-2, 1995.

     52. Grassi B., D.C. Poole, R.S. Richardson, D.R. Knight, B.K. Erickson, P.D. Wagner. Muscle O2 uptake kinetics in humans. Pflüg. Arch. 431: R345, 1996.

     53. Grassi B., L.B. Gladden, M. Samaja, C.M. Stary, M.C. Hogan. Unchanged muscle VO2 kinetics in the presence of a faster O2 delivery kinetics at the onset of contractions. Med. Sci. Sports Exerc. 29: S182, 1997.

     54. Hogan M.C., L.B. Gladden, B. Grassi, C.M. Stary, M. Samaja. Relationship between oxygen uptake and force production in contracting muscle after blood flow reduction. contractions. Med. Sci. Sports Exerc. 29: S26, 1997.

     55. Wagner P.D., B. Grassi, T.P. Gavin, L.J. Haseler, K. Tagore, J. Roca, G. Moore, R.S. Richardson. Hyperoxia increases VO2max in the isolated human quadriceps. Med. Sci. Sports Exerc. 29: S247, 1997.

     56. Kayser B., M. Marzorati, T. Binzoni, B. Grassi, C. Marconi, P. Cerretelli. Second generation lowland Tibetans lose less aerobic power at altitude than Caucasians. In: Hypoxia: Women at Altitude. Queen City Printers, Burlington, Vermont, USA, 1997 (p. 304). (Proceedings 10th International Hypoxia Symposium at Lake Louise, Canada).

     57. Grassi B., L.B. Gladden, M. Samaja, C.M. Stary, M.C. Hogan. Faster O2 delivery kinetics at the onset of contraction do not affect muscle VO2 kinetics. Riunione Primaverile “Società Italiana di Fisiologia”. Florence (I), March 25-27, 1997.

     58. Grassi B., V. Quaresima, C. Marconi, M. Ferrari. Is blood lactate increase at submaximal oxygen consumption associated with muscle anaerobiosis? BiOS Europe ’97 - European Biomedical Optics Week. Sanremo (I), September 7-8, 1997.

     59. Samaja M., S. Allibardi, G. Milano, G. Neri, B. Grassi, L.B. Gladden, M.C. Hogan. Differential effects of lactate and H+ on performance and metabolism in the rat heart. FASEB Journal 12: A998, 1998.

     60. Marconi C., S. Pogliaghi, B. Grassi, E. Rasia Dani, A. Colombini, P. Cerretelli. Energy metabolism at 7,600 m. FASEB Journal 12: A724, 1998.

     61. Grassi B., L.B. Gladden, C.M. Stary, P.D. Wagner, M.C. Hogan. Peripheral O2 diffusion does not limit muscle O2 uptake on-kinetics. Med. Sci. Sports Exerc. 30: S68, 1998.

     62. Quaresima V., B. Grassi, C. Marconi, M. Ferrari, P. Cerretelli. Blood lactate accumulation is associated with accelerated muscle deoxygenation. Med. Sci. Sports Exerc. 30: S67, 1998.

     63. Grassi B., C. Marconi, T. Amatya, P. Cerretelli. Lactate metabolism during exercise in chronic hypoxia. Third National Science Conference, Kathmandu (Nepal), March 8-11, 1999.

     64. Marconi C., B. Grassi, B. Basnyat, P. Cerretelli. Gas exchange at high altitude. Third National Science Conference, Kathmandu (Nepal), March 8-11, 1999.

     65. Grassi B., M.C. Hogan, K.M. Kelley, W.G. Aschenbach, J.J. Hamann, R.K. Evans, R.E. Patillo, and L.B. Gladden. Faster O2 delivery speeds VO2 on-kinetics in canine muscle contracting at peak VO2. Med. Sci. Sports Exerc. 31: S224, 1999.

     66. Gladden L.B., B. Grassi, K.M. Kelley, W.G. Aschenbach, J.J. Hamann, R.K. Evans, R.E. Patillo, M.C. Hogan. Blood flow during and between tetanic contractions in canine skeletal muscle. Med. Sci. Sports Exerc. 31: S353, 1999.

     67. Fukuoka Y., B. Grassi, M. Conti, S. Anchisi, A. Colombini, D. Guiducci, M. Sutti, C. Marconi, P. Cerretelli. Early effects of exercise training on VO2 on- and off- kinetics in 50-year old subjects. Med. Sci. Sports Exerc. 31: S382, 1999.

     68. Grassi B., S. Pogliaghi, S. Rampichini, M.C. Hogan, L.B. Gladden. VO2 on-kinetics for functional evaluation of myopathy patients. VIII Telethon Convention; Rimini (I); November 14-16, 1999.

     69. Cerretelli P., B. Grassi. MRS and NIRS vs. gas exchange assessment of metabolic transients in skeletal muscle. Society for Integrative and Comparative Biology Annual Meeting; Atlanta, Georgia (USA); January 4-8, 2000.

     70. Samaja M., M. Gatto, B. Grassi. Microspheres release in ischemic and hypoxic isolated hearts. FASEB J. 14: A142, 2000.

     71. Grassi B., S. Rampichini, C. Marconi, V. Quaresima, M. Ferrari, P. Cerretelli. On-kinetics of muscle oxygenation during constant-load cycling. Med. Sci. Sports Exerc. 32: S248, 2000.

     72. Marconi C., B. Grassi, M. Marzorati, P. Cerretelli. Peak exercise at high altitude. Med. Sci. Sports Exerc. 32: S48, 2000.

     73. Hogan M.C., B. Grassi, M. Samaja, C.M. Stary, L.B. Gladden. Muscle pump contribution to blood flow in contracting canine skeletal muscle with varied duty cycles and hypotension. Med. Sci. Sports Exerc. 32: S249, 2000.

     74. Cerretelli P., C. Marconi, B. Grassi. Lactic capacity: its regulation during altitude acclimatization and deacclimatization. IV World Congress of Mountain Medicine and High Altitude Physiology. Arica (Chile); October 1-6, 2000.

     75. Grassi B., S. Pogliaghi, S. Rampichini, M.C. Hogan, L.B. Gladden. VO2 on-kinetics for functional evaluation of myopathy patiens. IX Telethon Convention; Rimini (I), November 12-14, 2000.

     76. Pogliaghi S., B. Grassi, S. Rampichini, V. Quaresima, M. Ferrari, P. Cerretelli. On-kinetics of muscle oxygenation during constant-load cycling at different workloads. Med. Sci. Sports Exerc. 33: S330, 2001.

     77. Borrelli E., S. Pogliaghi, B. Grassi, P. Cerretelli. Longitudinal evaluation of exercise performance during the first 2 years after heart transplantation. Med. Sci. Sports Exerc. 33: S62, 2001.

     78. Gladden L.B., M.C. Hogan, P.L. Greenhaff, J.J. Hamann, K.M. Kelley, W.G. Aschenbach, D. Constantin-Teodosiu, B. Grassi. Metabolic effects of PDC activation in dog gastrocnemius in situ. Med. Sci. Sports Exerc. 33: S328, 2001.

     79. Grassi B., M.C. Hogan, K.M. Kelley, J.J. Hamann, W.G. Aschenbach, S. Rampichini, and L.B. Gladden. Peripheral O2 diffusion and VO2 on-kinetics in canine muscle at peak VO2. Med. Sci. Sports Exerc. 33: S329, 2001.

     80. Kelley K.M., R.A. Howlett, L.B. Gladden, B. Grassi, M.C. Hogan. Kinetics of metabolic activation in canine muscle in situ at the onset of high intensity contractions. Med. Sci. Sports Exerc. 33: S278, 2001.

     81. Grassi B., L. Morandi, S. Pogliaghi, S. Rampichini, C. Marconi, P. Cerretelli. Functional evaluation of patients with metabolic myopathies during exercise. Med. Sci. Sports Exerc. 34: S78, 2002.

     82. Gladden L.B., M.C. Hogan, K.M. Kelley, J.L. Dobson, B. Grassi. Metabolic response time of canine skeletal muscle. Med. Sci. Sports Exerc. 34: S79, 2002.

     83. Cerretelli P., A. Vezzoli, B. Grassi. MRS and NIRS assessment of muscle function in man. VII Annual Congress, European College of Sport Science; Athens (Greece); July 24-28, 2002.

     84. Morandi L., B. Grassi, S. Pogliaghi, C. Marconi, P. Cerretelli. Functional evaluation during exercise of patients with metabolic myopathies. 7th International Congress, World Muscle Society; Rotterdam (The Netherlands); October 2-5, 2002.

     85. Grassi B., L. Morandi, M. Spelta, M. Marzorati, A. Ferri, S. Pogliaghi, S. Rampichini, C. Marconi, P. Cerretelli. Functional evaluation of oxidative metabolism in patients with metabolic myopathies. Thelethon Convention 2002, Riva del Garda, TN (Italy); 24-26 November 2002.

     86. Howlett R.A., K.M. Kelley, B. Grassi, L.B. Gladden, M.C. Hogan. Supraphysiological caffeine administration does not restore force production in fatigued canine skeletal muscle. Experimental Biology 2003, San Diego, CA (USA); April 11-15, 2003.

     87. Grassi B., M.C. Hogan, K.M. Kelley, R.A. Howlett, R.E. Pattillo, L.B. Gladden. Effects of L-NAME during metabolic transitions in isolated canine muscle. Med. Sci. Sports Exerc. 35: S227, 2003.

     88. Ferri A., M. Marzorati, F. Lanfranconi, A. Colombini, A. Marchi, P. Capodaglio, B. Grassi. Systemic and “peripheral” effects of exercise training on oxidative metabolism in >75 years old subjects. 8th Annual Congress, European College of Sport Science; Salzburg (Austria); July 9-12, 2003.

     89. Pogliaghi S., F. Balestrieri, A. Cevese, B. Grassi, F. Schena. Effect of aerobic training on muscle oxygenation during incremental exercise in healthy elderly. American College of Sports Medicine 51st Annual Meeting; Indianapolis, IN (USA); June 2-5, 2004.

     90. Ferri A., M. Marzorati, S. Adamo, F. Lanfranconi, A. Colombini, P. Capodaglio, A. Marchi, B. Grassi. Absence of a slow component of pulmonary VO2 kinetics in very old subjects. American College of Sports Medicine 51st Annual Meeting; Indianapolis, IN (USA); June 2-5, 2004.

     91. Lanfranconi F., E. Borrelli, A. Ferri, F. Diciolla, M. Chiavarelli, B. Grassi. Central and peripheral factors limiting exercise tolerance in untrained heart transplant recipients. IX Annual Congress5t, European College of Sport Science; Clermont-Ferrand (France); July 3-6, 2004.

     92. Ferri A., M. Marzorati, S. Adamo, F. Lanfranconi, M. Longaretti, A. Colombini, B. Grassi. Pulmonary gas exchange and muscle oxygenation kinetics in >75 yr-old subjects. 32nd Annual Conference, International Society of Oxygen Transport to Tissues (ISOTT). Bari (I), August 21-26, 2004.

     93. Lanfranconi F., E. Borrelli, A. Ferri, F. Diciolla, M. Chiavarelli, B. Grassi. Impaired O2 extraction contributes to the reduced exercise tolerance in heart transplant recipients. 32nd Annual Conference, International Society of Oxygen Transport to Tissues (ISOTT). Bari (I), August 21-26, 2004.

     94. Grassi B., M. Marzorati, F. Lanfranconi, A. Ferri, M. Longaretti, C. Mauri, C. Marconi, L. Morandi. New tools of functional evaluation of patients with metabolic myopathies. XIII Scientific Convention, Telethon. Salsomaggiore Terme (I), March 6-8, 2005.

     95. Grassi B., C. Mauri, M. Marzorati, F. Lanfranconi, A. Ferri, M. Longaretti, L. Morandi. Near-infrared spectroscopy in the evaluation of O2 extraction in patients with metabolic myopathies. 52nd Annual Meeting, American College of Sports Medicine. Nashville, TN (USA); June 1-4, 2005.

     96. Ferri A., M. Longaretti, S. Adamo, F. Lanfranconi, M. Marzorati, A. Colombini, B. Grassi. Insights into central and peripheral factors affecting “oxidative performance” in ageing. 10th Annual Congress, European College of Sport Science; Belgrade (Serbia – Montenegro); July 13-16, 2005.

     97. Grassi B., M.C. Hogan, H.B. Rossiter, R.A. Howlett, J.E. Harris, M.L. Goodwin, J.L. Dobson, L.B. Gladden. Effects of acute creatine kinase inhibition on skeletal muscle O2 uptake kinetics. Med. Sci. Sports Exerc. 38: S519, 2006.

     98. Porcelli S., M. Marzorati, S. Mazzoni, P. Vago, B. Grassi. Functional evaluation of skeletal muscle oxidative metabolism in microgravity-induced muscular atrophy: analysis of VO2 kinetics. 1° Convegno Nazionale – Biomedicina e Spazio. Società Italiana di Biomedicina e Biotecnologia Spaziale. Monte Porzio Catone (Roma). March 14-15, 2006.

     99. Porcelli S., M. Marzorati, S. Mazzoni, P. Vago, B. Grassi. Functional evaluation of skeletal muscle oxidative metabolism in microgravity-induced muscular atrophy: near-infrared spectroscopy. 1° Convegno Nazionale – Biomedicina e Spazio. Società Italiana di Biomedicina e Biotecnologia Spaziale. Monte Porzio Catone (Roma). March 14-15, 2006.

     100. Ferri A., S. Adamo, M. Longaretti, F. Lanfranconi, M. Marzorati, A. Colombini, B. Grassi. There is no electromyographic threshold during incremental exercise in elderly subjects. XI Congress, European College of Sport Science. Lausanne (CH); July 5-8, 2006.

     101. Zoladz J.A., B. Grassi, B. Korzeniewski. Training-induced acceleration of oxygen uptake kinetics in skeletal muscle – the underlying mechanisms. Session: Adaptive responses of muscle metabolism to exercise. XXIII Congress of the Polish Physiological Society. “Physiology without limits”. Warsaw, Poland; September 15-16, 2006.

     102. Grassi B., S. Porcelli, M. Marzorati, F. Lanfranconi, P. Vago, C. Marconi, L. Morandi. New tools of functional evaluation of patients with metabolic myopathies. XIV Convention Scientifica – Telethon 2007. Salsomaggiore Terme (I), March 12-14, 2007.

     103. Porcelli S., M. Marzorati, S. Adamo, J. Gondin, R. Bottinelli, B. Grassi. Effects of increases in muscle size and force on oxidative metabolism. II Convegno Nazionale ISSBB (Italian Society for Space Biomedicine and Biotechnology. Bari (I); March 29-31, 2007.

     104. Harris J.E., B. Grassi, H.B. Rossiter, M.C. Hogan, M.L. Goodwin, J.L. Dobson, L.B. Gladden. Skeletal muscle function with acute creatine kinase inhibition. Experimental Biology ’07. Washington, DC (USA); April 28 – May 2, 2007.

     105. Ferri A., G. Watson, P. Laursen, B. Grassi, G. Miserocchi, D. Bishop. Influence of muscle fiber composition on oxygen uptake kinetics. Med. Sci. Sports Exerc. 39 (Suppl. 5): S359, 2007.

     106. Grassi B., S. Porcelli, M. Marzorati, S. Adamo, M. Castellini, J. Gondin, R. Bottinelli. Effects of strength training by electrostimulation on skeletal muscle oxidative metabolism. Med. Sci. Sports Exerc. 39 (Suppl. 5): S408, 2007.

     107. Lanfranconi F., S. Porcelli, M. Marzorati, P. Vago, F. Casamassima, B. Grassi. Central and peripheral limitations to oxidative metabolism after bed rest. III Congresso Nazionale, Società Italiana di Biomedicina e Biotecnologia Spaziale. Udine (I); April 2-3, 2008.

     108. Morandi L., S. Porcelli, M. Marzorati, F. Lanfranconi, B. Grassi. Nuovi metodi di valutazione funzionale di pazienti con miopatie metaboliche. 8° Congresso Nazionale Associazione Italiana di Miologia. Pisa (I); June 5-7, 2008.

     109. Vago P., F. Lanfranconi, M. Marzorati, S. Porcelli, L. Morandi, B. Grassi.Functional evaluation of oxidative energy metabolism in myopathic patients. 13th Annual Congress, European College of Sport Science. Estoril (P); July 9-12, 2008.

     110. Lai N., J. Spires, G.M. Seidal, B. Grassi, L.B. Gladden, M. Cabrera. Oxygen transport and metabolism in working skeletal muscle: role of glycolysis. Biomedical Engineering Society (BMES) 2008 Annual Fall Meeting. St. Louis, Missouri (USA); Oct. 2-4, 2008.

     111. Morandi L., Marzorati M., Porcelli S. Marconi C., Salvadego D., Lazzer S., Francescato M., di Prampero P.E., Grassi B. New methods of functional evaluation of patients with metabolic myopathies. The effects of exercise training. XV Scientific Convention – Telethon. Riva del Garda (I); March 9-11, 2009.

     112. Porcelli S., Marzorati M., Lanfranconi F., Vago P., Grassi B. Oxidative metabolism during exercise after bed rest: “central” and “peripheral” limitations. IV National Congress, Italian Society of Space Biomedicine and Biotechnology (ISSBB). S. Margherita Ligure (I); March 31 – April 2, 2009.

     113. di Prampero P.E., Rejc E., Lazzer S., Antonutto G., Salvadego D., Grassi B., Porcelli S., Marzorati M., Simunic B., Pisot. R. Effetti dell’allettamento prolungato sul deficit bilaterale e sulla massima potenza esplosiva degli arti inferiori. XXIII Convegno Nazionale. Associazione Italiana di Medicina Aeronautica e Spaziale. Napoli (I); May 20-22, 2009.

     114. Grassi B., Salvadego D., Lazzer S., Busti C., Galli R., Agosti F., Lafortuna C., Sartorio A. Gas exchange kinetics during exercise in obese adolescents. Inferences on exercise tolerance and prescription. Med. Sci. Sports Exerc. 42 (Suppl. 5): S19, 2010.

     115. Salvadego D., Lazzer S., Marzorati M., Porcelli S., Rejc E., di Prampero P.E., Grassi B. Impairment of skeletal muscle oxidative metabolism during knee-extension exercise after bed rest. Med. Sci. Sports Exerc. 42 (Suppl. 5): S362, 2011.

116. Monici M., Cialdai F., Grassi B., Strollo F., di Prampero P.E. Advanced laser systems. Perspectives for application in space medicine. Congress “Life in Space for Life on Earth” – European Space Agency. Trieste (I): June 13-18, 2010.

117. Salvadego D., Lazzer S., Marzorati M., Porcelli S., Rejc E., Pišot R., di Prampero P.E., Grassi B. The role of skeletal muscle in the limitation of maximal O2 uptake following bed rest. Congress “Life in Space for Life on Earth” – European Space Agency. Trieste (I): June 13-18, 2010.

118. Wust R.C.I., Grassi B., Hogan M.C., Howlett R.A., Gladden L.B., Rossiter H.B. A simple phosphate feedback control mechanism does not explain the kinetics of canine skeletal muscle oxygen consumption. Congress “Physiology 2010” – The Physiological Society. University of Manchester (UK): June 30 – July 2, 2010.

119. Marzorati M., Porcelli S., Belletti M., Grassi B., Morandi L. Improved exercise tolerance after enzyme replacement therapy in late-onset glycogen storage disease type II: report of a case. XII International Congress on Neuromuscular Diseases. Satellite Meeting: Muscle Fatigue in Neuromuscular Disorders: Pathogenic Mechanisms and Treatment. Pisa (I): July 23 -24, 2010.

120. Salvadego D., Lazzer S., Porcelli S., Marzorati M., Rejc E., Šimunič B., Pišot R., di Prampero P.E., Grassi B. Bed rest impairs skeletal muscle oxidative function independently from constraints related to cardiovascular O2 delivery. XXXIX European Muscle Conference – EMC 2010. Padova (I): Sept. 11-15, 2010.

121. McDonald J.R., Grassi B., Lai N., Hogan M.C., Sun Y., Gladden L.B. Effect of hypoxia with matched convective O2 delivery on V’O2 on-kinetics in canine skeletal muscle in situ. ACSM Conference: Integrative Physiology of Exercise. Miami Beach, FL (USA): Sept. 22-25, 2010.

122. Lai N., Spires J., Grassi B., Gladden L.B., Saidel G.M. Analysis of oxygen diffusion limitation in contracting skeletal muscle during higher ATP demand. ACSM Conference: Integrative Physiology of Exercise. Miami Beach, Florida (USA): Sept. 22-25, 2010.

     123. Marzorati M., Porcelli S., Belletti M., Salvadego D., Morandi L., Grassi B. New methods of functional evaluation of patients with metabolic myopathies. The effects of exercise training. XVI Convention Scientifica Telethon. Riva del Garda, TN (I). March 7-9, 2011.

     124. Rejc E., Lazzer S., Antonutto G., Grassi B., Šimunič B., di Prampero P.E. A 35-day bed rest decreases the bilateral deficit during explosive efforts of the lower limbs. Med. Sci. Sports Exerc. 43 (Suppl. 5): S570, 2011.

     125. Porcelli S., Marzorati M., Belletti M., Morandi L., Grassi B. The “second wind” phenomenon in McArdle patients during a second bout of submaximal constant-load exercise. Med. Sci. Sports Exerc. 43 (Suppl. 5): S526-S527, 2011.

     126. Salvadego D., Domenis R., Lazzer S., Porcelli S., Rizzo G., Simunic B., Pišot R., Rittweger J., Mavelli I., di Prampero P.E, Grassi B. Does extreme muscle hypertrophy determine an impairment of skeletal muscle oxidative metabolism? Med. Sci. Sports Exerc. 43 (Suppl. 5): S50, 2011.

     127. Salvadego D., Domenis R., Lazzer S., Porcelli S., Rizzo G., Simunic B., Pišot R., Mavelli I., di Prampero P.E, Grassi B. Effects of marked skeletal muscle hypertrophy in humans on oxidative function in vivo and in vitro. Acta Physiologica 203 (Suppl. 688): 42, 2011.

     128. Salvadego D., Keramidas M.E., Eiken O., Mekjavic I.R., Grassi B. Effects of hypoxia and microgravity on skeletal muscle oxidative metabolism. V Congresso Nazionale, Italian Society of Space Biomedicine and Biotechnology. Padova (I). November 17-19, 2011.

     129. Morandi L., Porcelli S., Grassi B., Marzorati M. Improved exercise tolerance after enzyme replacement therapy in late-onset glycogen-storage disease type II. 5th European Symposium “Steps Forward in Pompe Disease”, Budapest (H), Dec. 1-3, 2011.

     130. Salvadego D., Keramidas M.E., Domenis R., Mavelli I., Eiken O., Mekjavic I.B., Grassi B. Combined effects of bed rest and hypoxia on skeletal muscle oxidative function. Med. Sci. Sports Exerc. 44 (Suppl. 5): S24, 2012.

     131. Lazzer S., Salvadego D., Porcelli S., Rejc E., Busti C., Galli R., Agosti F., Sartorio A., Grassi B. Impairment of skeletal muscle oxidative metabolism during knee-extension exercise in severely obese women. Med. Sci. Sports Exerc. 44 (Suppl. 5): S344, 2012.

     132. Benson A.P., Grassi B., Rossiter H.B. Optimising and validating a computational model of the influence of circulatory dynamics on V’O2 kinetics. Med. Sci. Sports Exerc. 44 (Suppl. 5): S385-S386, 2012.

     133. Grassi B., Salvadego D., Patrizi A., Tringali G., Agosti F. Sartorio A. Helium breathing abolishes the slow component of pulmonary oxygen uptake kinetics in obese adolescents. Med. Sci. Sports Exerc. 44 (Suppl. 5): S386, 2012.

     134. Salvadego D., Keramidas M.E., Domenis R., Mavelli I., Eiken O., Mekjavic I.B., Grassi B. Site of impairment of oxidative function after 10-day normoxic or hypoxic bed rests. Life in Space for Life on Earth Symposium. Aberdeen (UK), June 18-22, 2012.

     135. Benson A.P., Grassi B., Rossiter H.B. A validated and optimized model linking muscle and pulmonary oxygen uptake kinetics. VPH 2012 Meeting – Integrative Approaches to Computational Biomedicine, Virtual Physiological Human Network of Excellence, FP7 Programme. London (UK), September 18-20, 2012.

     136. Salvadego D., Keramidas M.E., Domenis R., Mavelli I., Eiken O., Mekjavic I.B., Grassi B. Combined hypoxia and bed rest for 10 days on skeletal muscle oxidative metabolism in vivo and ex vivo. Acta Physiologica 206 (Suppl. 692): 41, 2012.

     137. Salvadego D., Agosti F., Tringali G., Patrizi A., Gattico A., Sartorio A., Grassi B. Respiratory muscle training lowers the O2 cost of cycling and improves exercise tolerance in obese adolescents. 60th Annual Meeting, American College of Sports Medicine. Indianapolis, Indiana (USA); May 28-June 1, 2013.

     138. Salvadego D., Agosti F., Tringali G., Patrizi A., Gattico A., Sartorio A., Grassi B. O2 cost of cycling, respiratory muscles training and exercise tolerance in obese adolescents. SIF 2013 Annual Meeting. Ancona (I), Sept. 18-21, 2013.

139.Salvadego D., Keramidas M.E., Domenis R., Mavelli I., Eiken O., Mekjavic I.B., Grassi B. Effects of hypoxia and microgravity on mitochondrial respiration and skeletal muscle oxidative function. 61st Annual Meeting, American College of Sports Medicine. Orlando, Florida (USA); May 27-June 1, 2014.

140. Porcelli S., Marzorati M., Bellistri G., Morandi L., Grassi B. New methods of functional evaluation of patients with metabolic myopathies. The effects of exercise training. 19th Annual Congress, European College of Sports Science. Amsterdam (The Netherlands): July 2-5, 2014.

141. Sechi A., Salvadego D., Dardis A., Romanello M., Da Ponte A., Bembi B., Grassi B. Does ERT induce an acute improvement in exercise tolerance in late onset Pompe patients? Annual Symposium, Society for the Study of Inborn Errors of Metabolism; Innsbruck, Austria; September 2-5, 2014.

142. Salvadego D., Keramidas M.E., Mavelli I., Eiken O., Mekjavic I.B., Grassi B. Skeletal muscle oxidative function: the separate and combined effects of unloading and hypoxia. 65th Congress of the Italian Physiological Society. Anacapri (I); September 28th-30th, 2014.

     143. Sechi A., Salvadego D., Dardis A., Romanello M., Da Ponte A., Bembi B., De Vigili G., Grassi B. Acute effect of enzyme replacement therapy on exercise tolerance in late onset Pompe patients. 11th Annual WORLD Symposium. Orlando, Florida (SA); February 9-13, 2015.

144. Salvadego D., Keramidas M.E., Kölegård R., Mavelli I., Eiken O., Mekjavic I.B., Grassi B. Prolonged exposure to hypoxia and microgravity: effects on skeletal muscle oxidative metabolism. 62nd Annual Meeting, American College of Sports Medicine. San Diego, California (USA); May 26-30, 2015.

145. Salvadego D., Keramidas M.E., Kölegård R., Mavelli I., Eiken O., Mekjavic I.B., Grassi B. PlanHab: responses of skeletal muscle oxidative metabolism to bed rest and hypoxia. 36th Annual International Gravitational Physiology Meeting. Ljubljana (Slovenia); June 7-12, 2015.

146. Salvadego D., Keramidas M.E., Mavelli I., Eiken O., Mekjavic I.B., Grassi B. Impairment of skeletal muscle oxidative function in vivo following muscle disuse: what is the role of mitochondria? Congresso Annuale “Gruppo Italiano di Biomembrane e Bioenergetica”. Udine (I); June 18-20, 2015.

147. Rasica L., D. Salvadego, S. Porcelli, M. Marzorati, S. Mrakic-Sposta, S. Moretti, M. Montorsi, A. Sartorio, B. Grassi. Effects of dietary nitrate supplementation on exercise tolerance in obese patients. VII Congresso Annuale SISMeS (Società Italiana delle Scienze Motorie e Sportive). Padova (I): Oct. 2-4, 2015.

148. Ferguson B.S., McDonald J.R., Mowry F., Sun Y., Rasica L., Porcelli S., Hogan M.C., Grassi B., Gladden L.B. Effects of hypoxia with matched convective O2 delivery on fatigue and V’O2-on kinetics in canine skeletal muscle in situ. EB Experimental Biology 2016. San Diego, California (USA). April 2-6, 2016.

149. Rasica L., Porcelli S., Ferguson B.S., Kavazis A.N., McDonald J.R., Mowry F., Sun Y., Hogan M.C., Grassi B., Gladden L.B. Nitrate infusion does not alter isolated in situ canine oxidative metabolism during hypoxia with normal convective O2 delivery. Annual Meeting of Young Researchers in Physiology – Società Italiana di Fisiologia. Magnano in Riviera, UD (Italy): May 5-7, 2016.

150. Salvadego D., Keramidas M.E., Rittweger J., Mavelli I., Eiken O., Mekjaviv I.B., Grassi B. Muscle oxidative function in vivo following inactivity and hypoxic exposure: what is the role of mitochondria? Annual Meeting of Young Researchers in Physiology – Società Italiana di Fisiologia. Magnano in Riviera, UD (Italy): May 5-7, 2016.

151. Buso A., Comelli M., Isola M., Grassi B., Mavelli I. Mitochondrial bioenergetics- and biogenesis-related proteins adaptation following two weeks of bed rest and recovery in elderly and young men. Annual Meeting of Young Researchers in Physiology – Società Italiana di Fisiologia. Magnano in Riviera, UD (Italy): May 5-7, 2016.

152. Biasutti L., Blanco R., Corbellini Bressan M., Bizzarrini E., Grassi B. Oxidative metabolism during a wheelchair propulsion test in patients with spinal cord injury: effects of lesion level. Annual Meeting of Young Researchers in Physiology – Società Italiana di Fisiologia. Magnano in Riviera, UD (Italy): May 5-7, 2016.

153. Lai N., Pfaff N., Fiutem J.J., Shivapour J., Strainic J., Grassi B. Gender differences in the cardiorespiratory response to exercise using a modified Bruce protocol in children. 63rd Annual Meeting, American College of Sports Medicine. Boston, MA (USA). May 31-June 4, 2016.

154. Zuccarelli L., Rasica L., Marzorati M., Porcelli S., Grassi B. Importance of slow components of HR and V’O2 kinetics during submaximal cycling on exercise intensity prescription. 21st Annual Congress, European College of Sports Science. Vienna (Austria). July 6-9, 2016.

155. Marusic U., Taube W., Morrison S.A., Simunic B., Biasutti L., Grassi B., Pisot R. Mental simulation of locomotor tasks improves rehabilitation outcome in elderly adults after hip surgery. 21st Annual Congress, European College of Sports Science. Vienna (Austria). July 6-9, 2016.

156. Rasica L., Salvadego D., Porcelli S., Marzorati M., Moretti S., Sartorio A., Grassi B. Dietary nitrate supplementation and exercise tolerance in obese adolescents. 21st Annual Congress, European College of Sports Science. Vienna (Austria). July 6-9, 2016.

157. Pisot R., Marusic U., Biolo G., Mazzucco S., Lazzer S., Grassi B., di Prampero P.E., Passaro A., Narici M., Rittweger J., Gasparini M., Paravic A., Simunic B. Functional and metabolic alterations in younger and older men after 14-day bed rest with 14-day recovery. 21st Annual Congress, European College of Sports Science. Vienna (Austria). July 6-9, 2016.

158. Porcelli S., Rasica L., Ferguson B.S., Kavazis A.N., McDonald J.R., Mowry F., Hogan M.C., Grassi B., Gladden L.B. Nitrite infusion does not alter isolated canine muscle oxidative metabolism in situ during hypoxia with normal convective O2 delivery. Experimental Biology 2017. Chicago, IL (USA). April 22-26, 2017.

159. do Nascimento Salvador P.C., de Lucas B.D., Grassi B., Guglielmo L.G.A., Denadai B.S. What causes the V’O2 slow component during exercise above critical power? 22nd Annual Congress, European College of Sport Science. Bochum – Dortmund – Duisburg – Essen (D). July 5-8, 2017.

160. Guglielmo L.G.A, Estrela R.L.D., Bittencourt M.A., do Nascimento Salvador P.C., de Lucas R.D., Grassi B. Acute effect of caffeine ingestion on V’O2 slow component and muscle fatigue during a high-intensity cycling exercise. 22nd Annual Congress, European College of Sport Science. Bochum – Dortmund – Duisburg – Essen (D). July 5-8, 2017.

161. Biasutti L., Blanco R., Bizzarini E., Grassi B. Oxidative metabolism during a wheelchair propulsion test in patients with spinal cord injury. 22nd Annual Congress, European College of Sport Science. Bochum – Dortmund – Duisburg – Essen (D). July 5-8, 2017.

162. Alemayehu H.K., Salvadego D., Isola M., Tringali G., De Micheli R., Caccavale M., Sartorio A., Grassi B. Three weeks of respiratory muscle endurance training decrease the O2 cost of walking in obese adolescents. 65th Annual Meeting, American College of Sports Medicine. Minneapolis, Minnesota (USA); May 29-June 3, 2018.

163. Zuccarelli L., Rasica L., Marzorati M., Porcelli S., Grassi B. Comparison between the slow components of HR kinetics and of V’O2 kinetics: functional significance. 65th Annual Meeting, American College of Sports Medicine. Minneapolis, Minnesota (USA); May 29-June 3, 2018.

164. Pedrali M., Zuccarelli L., Biasutti L., Azzini V., Rasica L., Marzorati M., Porcelli S., Sechi A., Grassi B. Exercise tolerance in late-onset Pompe disease patients: positive effects of physical training and high-protein diet.23rd Annual Congress, European College of Sport Science. Dublin (E). July 4-7, 2018.

165. Ferri A., Adamo S., Longaretti M., Lanfranconi F., Marzorati M., Grassi B. Pulmonary, heart rate and muscle deoxygenation kinetics in very old individuals. 23rd Annual Congress, European College of Sport Science. Dublin (E). July 4-7, 2018.

166. Alemayehu H.K., Salvadego D., Tringali G., De Micheli R., Caccavale M., Sartorio A., Grassi B. Respiratory muscle unloading by normoxic helium-O2 breathing during cycling exercise delays volitional exhaustion in obese adolescents. ACSM Conference on Integrative Physiology of Exercise. San Diego, CA (USA). Sept. 5-8, 2018.

167. Zuccarelli L., Do Nascimento Salvador P.C., Del Torto A., Fiorentino R., Grassi B. Skeletal muscle V’O2 kinetics by NIRS “repeated occlusions method” during recovery from cycle ergometer exercise. 66th Annual Meeting, American College of Sports Medicine. Orlando, Florida (USA); May 28-June 1, 2019.

168. Ferri A., Adamo S., Longaretti M., Lanfranconi F., Marzorati M., Grassi B. Pulmonary and heart rate off-transient kinetics in very old individuals. 24th Annual Congress, European College of Sport Science. Prague (CZ). July 3-6, 2019.

169. Magnesa B., Comelli M., Mavelli I., Vaccari F., Passaro A., Lazzer S., Grassi B. Endurance training improves skeletal muscle mitochondrial function in obese subjects. 24th Annual Congress, European College of Sport Science. Prague (CZ). July 3-6, 2019.

170. Allam M., Teso M., Borrelli E., Grassi B., Pogliaghi S. Oxygen uptake efficiency slope can accurately track changes of cardiorespiratory fitness early after heart transplant. Joint Meeting FEPS (Federation of the European Physiological Societies) –SIF (Società Italiana di Fisiologia). Bologna (I). September 10-13, 2019.

171.Zuccarelli L., Magnesa B., Degano C., Comelli M., Gasparini M., Manferdelli G., Marzorati M., Mavelli I., Pilotto A., Porcelli S., Rasica L., Šimunič B., Pišot R.,Narici M., Grassi B. The impairment of oxidative metabolism during exercise after 10 days of bed rest is upstream of skeletal muscle mitochondria. Med. Sci. Sports Exerc. 52 (5): S122, 2020.

172. Porcelli S., Rasica L., Zuccarelli L., Magnesa B., Degano C., Comelli M., Gasparini M., Manferdelli G., Marzorati M., Mavelli I., Pilotto A., Šimunič B., Pišot R.,Narici M., Grassi B. Effects of 10-day bed-rest on nitric oxide metabolites and microvascular function assessed by near-infared spectroscopy. 67th Annual Meeting, American College of Sports Medicine. San Francisco, California (USA); May 26-30, 2020.

173. Salvadego D., Grassi B., Keramidas M.E., Eiken O., Mekjavic I.B. Heterogeneity in the responses of oxidative function in vivo and ex vivo to normoxic and hypoxic bed rest. The Physiological Society, London, UK, Online Symposium: “Variability: how to deal with it, interpret it and learn from it”. October 5-6th, 2020.

174. Pilotto A.M., Mazzolari R., Colosio M., Grassi B., Porcelli S. Non-invasive evaluation of the time-course changes in physiological adaptations to low-volume high-intensity interval training. 25th Annual Congress, European College of Sport Science. Sevilla (ESP). October 28-30, 2020.

175.Baldassarre G., Zuccarelli L., Manferdelli G., Manfredini V., Rasica L., Pilotto A., Marzorati M., Porcelli S., Šimunic B., Pišot R., Narici M., Grassi B. Decrease in work rate in order to keep a constant heart rate: effects of a10-day bed rest. 25th Annual Congress, European College of Sport Science. Sevilla (ESP). October 28-30, 2020.

176. Zuccarelli L., Baldassarre G., Magnesa B., Degano C., Comelli M., Gasparini M., Manferdelli G., Marzorati M., Mavelli I., Pilotto A., Porcelli S., Rasica L., Šimunič B., Pišot R., Narici M., Grassi B.  Peripheral impairments of oxidative metabolism after a 10-day bed rest are upstream of mitochondrial respiration. 5th Human Physiology Workshop. DLR, Koln (D). December 5th 2020.

177.Baldassarre G., Zuccarelli L., Manferdelli G., Manfredini V., Rasica L., Pilotto A., Marzorati M., Porcelli S.,Šimunic B.,Pišot R., Narici M., Grassi B. Work rate decrease during exercise at a fixed submaximal heart rate: a new method to evaluate exercise (in)tolerance in microgravity? 5th Human Physiology Workshop. DLR, Koln (D). December 5th 2020.

178.Baldassarre G., Zuccarelli L., Manferdelli G., Manfredini V., Rasica L., Pilotto A., Marzorati M., Porcelli S.,Šimunic B.,Pišot R., Narici M., Grassi B.Work rate decrease at a fixed heart rate to evaluate exercise tolerance in microgravity. 68th Annual Meeting, American College of Sports Medicine. June 1-5, 2021.

179.Zuccarelli L., Baldassarre G., Magnesa B., Degano C., Comelli M., Gasparini M., Manferdelli G., Marzorati M., Mavelli I., Pilotto A., Porcelli S., Rasica L., Šimunič B., Pišot R., Narici M., Grassi B.  Short-term bed rest exposure impairs peripheral vascular and endothelial functions whereas mitochondrial respiration is unaffected. 68th Annual Meeting, American College of Sports Medicine. June 1-5, 2021.

180. Zuccarelli L, Baldassarre G, Grassi B. Comparison between slow components of heart rate and VO2 kinetics: functional significance and practical implications for exercise prescription. 71st National Congress, Società Italiana di Fisiologia; Milano (I); September 7-9, 2021.

180. Pilotto AM, Adami A, Mazzolari R, Brocca L, Crea E, Pellegrino MA, Bottinelli R, Zuccarelli L, Grassi B, Rossiter HB, Porcelli S. Near-infrared spectroscopy estimation of combined skeletal muscle oxidative capacity and O2 diffusion capacity in young healthy humans. 26th Annual Congress, European College of Sport Science (ECSS); September 8-10, 2021.

181. Gissi C, Zuccarelli L, Comelli M, Brocca L, Rossi M, Battini R, Uchida T, Pellegrino MA, Bottinelli R, Grassi B, Molinari S, Mavelli I. Increased MtCK and ANT1 in aging Pin1 KO mice as a basis of augmented ADP sensitivity of mitochondrial respiration. 61st National Congress, Società Italiana di Biochimica e Biologia Molecolare (SIB); September 23-24, 2021.

181. Zuccarelli L, Baldassarre G, Grassi B. Peripheral impairments of oxidative metabolism after 10 days of complete inactivity are upstream of mitochondrial respiration. XII Congress SISMeS (Società Italiana delle Scienze Motorie e Sportive). Padova (I); October 8-10, 2021.

182. Porcelli S, Salvadego D, Grassi B. Functional impairment of skeletal muscle oxidative metabolism in response to 35 days of complete inactivity. XII Congress SISMeS (Società Italiana delle Scienze Motorie e Sportive). Padova (I); October 8-10, 2021.

183. Baldassarre G, Azzini V, Zuccarelli V, Degano C, Graniero F, Plett G, Floreani M, Lazzer S, Mos L, Grassi B. In cardiac patients beta-blockers attenuate the decrease in work rate at a fixed heart rate. 69th Annual Meeting, American College of Sports Medicine. San Diego, CA (USA) May 31 - June 4, 2022.

184. Pilotto AM, Adami A, Mazzolari R, Brocca L, Crea E, Pellegrino MA, Bottinelli R, Zuccarelli L, Grassi B, Rossiter HB, Porcelli S. Near-infrared spectroscopy estimation of combined muscle oxidative capacity and oxygen diffusion capacity in humans. 69th Annual Meeting, American College of Sports Medicine. San Diego, CA (USA) May 31 - June 4, 2022.

185. Zuccarelli L, Baldassarre G, De Martino M, Isola M, Lippe G, Grassi B. Mitochondrial sensitivity to submaximal [ADP] following bed rest: a double-exponential model analysis. 69th Annual Meeting, American College of Sports Medicine. San Diego, CA (USA) May 31 - June 4, 2022.

186. GissiC, Comelli M, D’Este F, Moras G, Grassi B, Eckenweiler M, Carraro M, Zech M, Lippe G. A further characterization of a novel variant of ATP5MC3 associated with dystonia and spastic paraplegia. 21st European BioEnergetics Conference (EBEC), Aix-en-Provence, France; August 20-25, 2022.

187.Pilotto A, Mazzolari R, Turner D, Gorski P, Crea E, Zuccarelli L, Brocca L, Pellegrino M, Grassi B, Bottinelli R, Sharples A, Porcelli S. Human skeletal muscle possesses an epigenetic memory of high intensity interval training affecting mitochondrial function. American Physiology Summit. Long Beach, CA (USA). April 20-23, 2022.

188. Porcelli S, Marzorati M, Zuccarelli L, Bottinelli R, Grassi B. Home-based aerobic exercise training improves skeletal muscle oxidative metabolism in old people. 2023 On-site Padua Muscle Days on Muscle and Mobility Medicine (2023Pdm3). Padua – Montegrotto Terme (I), March 29-April 1, 2023.

 

Udine, January 16th 2023

 

                                                                                                                              

                                                                                           (Prof. Bruno Grassi)