POSITION: Fixed-term researcher at the Department of Medical and Biological Sciences in the competition sector 06/A4 Anatomical Pathology, pursuant to art. 24, clause 3, letter a) of Law n. 240 of 30.12.2010.
EDUCATION AND TRAINING
1998: MD degree; University of Udine; Faculty of Medicine. Degree grade: 110/110 with honors.
2002: Specialization in medical Oncology; University of Udine; Faculty of Medicine; School of specialization in Medical Oncology; Director: Prof. C.A. Beltrami. Degree grade: 70/70 with honors.
2006: PhD; University of Siena; Faculty of Medicine; PhD program in “Quantitative and molecular diagnostic pathology” - XVIII ciclo. Director: Prof. L. Leoncini.
HABILITATIONS
- Habilitation for Associate Professor in SSD 06/A4 ANATOMICAL PATHOLOGY, from 07/01/2014 to 07/01/2020.
- Habilitation for Associate Professor in SSD 05/F1 APPLIED BIOLOGY, from 22/01/2014 to 22/01/2020.
- Habilitation for Associate Professor in SSD 06/N1 SCIENCES OF HEALTH PROFESSIONS AND APPLIED MEDICAL TECHNOLOGIES, from 09/06/2014 to 09/06/2020.
RESEARCH ACTIVITY
June 2012-today:Coordination of the Biomedical Research Group within the European Grant, 7FP, Ideas, ERC Advanced Grant ”Molecular Nanotechnology For Life Science Application: QUantitative Interactomics for Diagnostics, Proteomics and QUantitative Oncology, (Quidroquo-QPQ-) proposal n. 269025. P.I. Prof. G. Scoles (http://monalisa.uniud.it/?q=daniela-cesselli). University of Udine, Department of Medical and Biological Sciences. The project overall aims to develop and apply the most innovative technologies for the understanding of highly debilitating and fatal diseases, such as cancer, heart disease and neurodegenerative diseases. Since nanotechnologies are particularly suitable for analytes and events that are small in number (e.g. stem cells and circulating tumor cells), or size (e.g. exosomes) or concentration (e.g. circulating miRNAs), we are exploring our clinical issues taking advantage of nano-devices for the study of patient-derived stem cells, exosomes and miRNAs. The ultimate goal is therefore to profoundly affect the life of patients by improving diagnostics, providing new prognostic systems and improving the criteria for the choice of the therapeutic strategy, pursuing, as much as possible, a personalized patient-based approach.
The group includes 2 Research Associates, 5 Post-Docs, 4PhD students.
July 2009 – July 2013: Principal investigator of Young Investigator Grant, Italian Ministry of Health, GR-2007-683407: “Employment of Adipose tissue derived Multipotent Adult Stem Cells for cardiovascular regeneration”. Interdepartmental Center of Regenerative Medicine; University of Udine
11/4/2011-18/4/2011: Research associate at the Experimental Cardiovascular Medicine
Bristol Heart Institute, Bristol Royal Infirmary, Bristol, UK. Collaboration with Prof. P. Madeddu in a project focused on the study of the impact of cardiac stem cell (CSC) senescence on the CSC regenerative potential.
6/3/2010-2/4/2010: Visiting scientist at the Brigham and Women's Hospital, Department of Anesthesia, Boston, MA, USA. Collaboration with Prof. A. Leri on a project focused on cardiac stem cell senescence
15/2/2009-29/2/2009; March-May 2005. Research associate at the Brigham and Women's Hospital, Department of Anesthesia, Boston, MA, USA. Collaboration with Prof. P. Anversa on a project focused on cardiac stem cell senescence
December 2006 – May 2010: Research scientist at the Interdepartmental Center of Regenerative Medicine; University of Udine. Organization and coordination of a research group focused on the study of human gliomas.
January 2003 – December 2008: Research activity at the Institute of Pathology held by Prof. C.A. Beltrami, University of Udine. Organization and coordination of a research group together with Dr A.P. Beltrami focused on the isolation and characterization of multipotent adult stem cells from several human tissues. Use of stem cells in cardiac, hepatic and neural regenerative medicine. Stem cells in human ovarian, liver and brain cancer.
January 2000 – January 2003: Research Fellow at the Cardiovascular Research Institute, New York Medical College, Valhalla, NY (USA) directed by Prof. P. Anversa. Identification and characterization of cardiac stem cell niches in a normal murine model.
SCIENTIFIC PRODUCTIONS
54 publications in peer-reviewed journals (total IF 317, H-index 23; i10index 32; total number of citation 2847; source: Google Scholar, 12-04-2016).
1. Bulfoni M, Gerratana L, Del Ben F, Marzinotto S, Sorrentino M, Turetta M, Scoles G, Toffoletto B, Isola M, Beltrami CA, Di Loreto C, Beltrami AP, Puglisi F, Cesselli D. In patients with metastatic breast cancer the identification of circulating tumor cells in epithelial-to-mesenchymal transition is associated with a poor prognosis. Breast Cancer Res. 2016;18(1):30.
2. Venturelli L, Nappini S, Bulfoni M, Gianfranceschi G, Dal Zilio S, Coceano G, Del Ben F, Turetta M, Scoles G, Vaccari L, Cesselli D, Cojoc D. Glucose is a key driver for GLUT1-mediated nanoparticles internalization in breast cancer cells. Sci Rep. 2016;6:21629.
3. Rapozzi V, Ragno D, Guerrini A, Ferroni C, Pietra ED, Cesselli D, Castoria G, Di Donato M, Saracino E, Benfenati V, Varchi G. Androgen Receptor Targeted Conjugate for Bimodal Photodynamic Therapy of Prostate Cancer in Vitro. Bioconjug Chem. 2015.
4. Meloni M, Cesselli D, Caporali A, Mangialardi G, Avolio E, Reni C, Fortunato O, Martini S, Madeddu P, Valgimigli M, Nikolaev E, Kaczmarek L, Angelini GD, Beltrami AP, Emanueli C. Cardiac Nerve Growth Factor Overexpression Induces Bone Marrow-derived Progenitor Cells Mobilization and Homing to the Infarcted Heart. Mol Ther. 2015.
5. Gianfranceschi G, Gri G, Cesselli D, Beltrami AP. Stem Cell Senescence as the Memory of Past Injuries. Current Pathobiology Reports. 2015;3(1):17-26.
6. Ganau M, Bosco A, Palma A, Corvaglia S, Parisse P, Fruk L, Beltrami AP, Cesselli D, Casalis L, Scoles G. A DNA-based nano-immunoassay for the label-free detection of glial fibrillary acidic protein in multicell lysates. Nanomedicine. 2015;11(2):293-300.
7. Domenis R, Lazzaro L, Calabrese S, Mangoni D, Gallelli A, Bourkoula E, Manini I, Bergamin N, Toffoletto B, Beltrami CA, Beltrami AP, Cesselli D, Parodi PC. Adipose tissue derived stem cells: in vitro and in vivo analysis of a standard and three commercially available cell-assisted lipotransfer techniques. Stem Cell Res Ther. 2015;6(1):2.
8. Avolio E, Meloni M, Spencer HL, Riu F, Katare R, Mangialardi G, Oikawa A, Rodriguez-Arabaolaza I, Dang Z, Mitchell K, Reni C, Alvino VV, Rowlinson JM, Livi U, Cesselli D, Angelini G, Emanueli C, Beltrami AP, Madeddu PR. Combined Intramyocardial Delivery of Human Pericytes and Cardiac Stem Cells Additively Improves the Healing of Mouse Infarcted Hearts Through Stimulation of Vascular and Muscular Repair. Circ Res. 2015.
9. Verardo R, Piazza S, Klaric E, Ciani Y, Bussadori G, Marzinotto S, Mariuzzi L, Cesselli D, Beltrami AP, Mano M, Itoh M, Kawaji H, Lassmann T, Carninci P, Hayashizaki Y, Forrest AR, Beltrami CA, Schneider C. Specific mesothelial signature marks the heterogeneity of mesenchymal stem cells from high-grade serous ovarian cancer. Stem Cells. 2014;32(11):2998-3011.
10. Mion F, Tonon S, Toffoletto B, Cesselli D, Pucillo CE, Vitale G. IL-10 production by B cells is differentially regulated by immune-mediated and infectious stimuli and requires p38 activation. Mol Immunol. 2014.
11. Magini A, Polchi A, Tancini B, Urbanelli L, Di Cristina M, Mannucci R, Nicoletti I, Emiliani C. Methods to discriminate the distribution of acidic glycohydrolases between the endosomal-lysosomal systems and the plasma membrane. Methods Enzymol. 2014;534:25-45.
12. Jovcevska I, Zupanec N, Kocevar N, Cesselli D, Podergajs N, Stokin CL, Myers MP, Muyldermans S, Ghassabeh GH, Motaln H, Ruaro ME, Bourkoula E, Turnsek TL, Komel R. TRIM28 and beta-actin identified via nanobody-based reverse proteomics approach as possible human glioblastoma biomarkers. PLoS One. 2014;9(11):e113688.
13. Fortini C, Cesselli D, Beltrami AP, Bergamin N, Caragnano A, Moretti L, Cecaro F, Aquila G, Rizzo P, Riberti C, Tavazzi L, Fucili A, Beltrami CA, Ferrari R. Alteration of Notch signaling and functionality of adipose tissue derived mesenchymal stem cells in heart failure. Int J Cardiol. 2014.
14. Domenis R, Bergamin N, Gianfranceschi G, Vascotto C, Romanello M, Rigo S, Vagnarelli G, Faggiani M, Parodi P, Kelley MR, Beltrami CA, Cesselli D, Tell G, Beltrami AP. The redox function of APE1 is involved in the differentiation process of stem cells toward a neuronal cell fate. PLoS One. 2014;9(2):e89232.
15. Cesselli D, Beltrami AP. Stem cell senescence in diabetes: forgetting the sweet old memories. Diabetes. 2014;63(6):1841-1843.
16. Bourkoula E, Mangoni D, Ius T, Pucer A, Isola M, Musiello D, Marzinotto S, Toffoletto B, Sorrentino M, Palma A, Caponnetto F, Gregoraci G, Vindigni M, Pizzolitto S, Falconieri G, De Maglio G, Pecile V, Ruaro ME, Gri G, Parisse P, Casalis L, Scoles G, Skrap M, Beltrami CA, Beltrami AP, Cesselli D. Glioma-associated stem cells: a novel class of tumor-supporting cells able to predict prognosis of human low-grade gliomas. Stem Cells. 2014;32(5):1239-1253.
17. Avolio E, Gianfranceschi G, Cesselli D, Caragnano A, Athanasakis E, Katare R, Meloni M, Palma A, Barchiesi A, Vascotto C, Toffoletto B, Mazzega E, Finato N, Aresu G, Livi U, Emanueli C, Scoles G, Beltrami CA, Madeddu P, Beltrami AP. Ex vivo molecular rejuvenation improves the therapeutic activity of senescent human cardiac stem cells in a mouse model of myocardial infarction. Stem Cells. 2014.
18. Andolfi L, Bourkoula E, Migliorini E, Palma A, Pucer A, Skrap M, Scoles G, Beltrami AP, Cesselli D, Lazzarino M. Investigation of adhesion and mechanical properties of human glioma cells by single cell force spectroscopy and atomic force microscopy. PLoS One. 2014;9(11):e112582.
19. Zeppieri M, Salvetat ML, Beltrami AP, Cesselli D, Bergamin N, Russo R, Cavaliere F, Varano GP, Alcalde I, Merayo J, Brusini P, Beltrami CA, Parodi PC. Human adipose-derived stem cells for the treatment of chemically burned rat cornea: preliminary results. Curr Eye Res. 2013;38(4):451-463.
20. Magini A, Polchi A, Urbanelli L, Cesselli D, Beltrami A, Tancini B, Emiliani C. TFEB activation promotes the recruitment of lysosomal glycohydrolases β-hexosaminidase and β-galactosidase to the plasma membrane. Biochemical and Biophysical Research Communications. 2013(0).
21. Katare R, Oikawa A, Cesselli D, Beltrami AP, Avolio E, Muthukrishnan D, Munasinghe PE, Angelini G, Emanueli C, Madeddu P. Boosting the pentose phosphate pathway restores cardiac progenitor cell availability in diabetes. Cardiovasc Res. 2013;97(1):55-65.
22. Garrovo C, Bergamin N, Bates D, Cesselli D, Beltrami AP, Lorenzon A, Ferrari R, Alberto Beltrami C, Lorusso V, Biffi S. In vivo tracking of murine adipose tissue-derived multipotent adult stem cells and ex vivo cross-validation. Int J Mol Imaging. 2013;2013:426961.
23. Cesselli D, D'Aurizio F, Marcon P, Bergamin N, Beltrami CA, Beltrami AP. Cardiac stem cell senescence. Methods Mol Biol. 2013;976:81-97.
24. Bergamin N, Dardis A, Beltrami A, Cesselli D, Rigo S, Zampieri S, Domenis R, Bembi B, Beltrami CA. A human neuronal model of Niemann Pick C disease developed from stem cells isolated from patient's skin. Orphanet J Rare Dis. 2013;8(1):34.
25. Ferro F, Spelat R, D'Aurizio F, Puppato E, Pandolfi M, Beltrami AP, Cesselli D, Falini G, Beltrami CA, Curcio F. Dental pulp stem cells differentiation reveals new insights in Oct4A dynamics. PLoS One. 2012;7(7):e41774.
26. Ferro F, Spelat R, D'Aurizio F, Falini G, De Pol I, Pandolfi M, Beltrami AP, Cesselli D, Beltrami CA, Curcio F. Acellular bone colonization and aggregate culture conditions diversely influence murine periosteum mesenchymal stem cell differentiation potential in long-term in vitro osteoinductive conditions. Tissue Eng Part A. 2012;18(13-14):1509-1519.
27. Ferro F, Spelat R, Beltrami AP, Cesselli D, Curcio F. Isolation and characterization of human dental pulp derived stem cells by using media containing low human serum percentage as clinical grade substitutes for bovine serum. PLoS One. 2012;7(11):e48945.
28. Beltrami AP, Cesselli D, Beltrami CA. Stem cell senescence and regenerative paradigms. Clin Pharmacol Ther. 2012;91(1):21-29.
29. Beltrami A, Cesselli D, Beltrami C. Cardiac Resident Stem Cells: Work (Still) in Progress. J Stem Cell Res Ther 2012;S9:001.
30. Amadesi S, Reni C, Katare R, Meloni M, Oikawa A, Beltrami AP, Avolio E, Cesselli D, Fortunato O, Spinetti G, Ascione R, Cangiano E, Valgimigli M, Hunt SP, Emanueli C, Madeddu P. Role for substance p-based nociceptive signaling in progenitor cell activation and angiogenesis during ischemia in mice and in human subjects. Circulation. 2012;125(14):1774-1786, S1771-1719.
31. Katare R, Riu F, Mitchell K, Gubernator M, Campagnolo P, Cui Y, Fortunato O, Avolio E, Cesselli D, Beltrami AP, Angelini G, Emanueli C, Madeddu P. Transplantation of human pericyte progenitor cells improves the repair of infarcted heart through activation of an angiogenic program involving micro-RNA-132. Circ Res. 2011;109(8):894-906.
32. Katare R, Caporali A, Zentilin L, Avolio E, Sala-Newby G, Oikawa A, Cesselli D, Beltrami AP, Giacca M, Emanueli C, Madeddu P. Intravenous gene therapy with PIM-1 via a cardiotropic viral vector halts the progression of diabetic cardiomyopathy through promotion of prosurvival signaling. Circ Res. 2011;108(10):1238-1251.
33. Ferro F, Spelat R, Falini G, Gallelli A, D'Aurizio F, Puppato E, Pandolfi M, Beltrami AP, Cesselli D, Beltrami CA, Ambesi-Impiombato FS, Curcio F. Adipose tissue-derived stem cell in vitro differentiation in a three-dimensional dental bud structure. Am J Pathol. 2011;178(5):2299-2310.
34. Cesselli D, Beltrami AP, Poz A, Marzinotto S, Comisso E, Bergamin N, Bourkoula E, Pucer A, Puppato E, Toffoletto B, Sorrentino M, Baccarani U, Avellini C, Beltrami CA. Role of tumor associated fibroblasts in human liver regeneration, cirrhosis, and cancer. Int J Hepatol. 2011;2011:120925.
35. Cesselli D, Beltrami AP, D'Aurizio F, Marcon P, Bergamin N, Toffoletto B, Pandolfi M, Puppato E, Marino L, Signore S, Livi U, Verardo R, Piazza S, Marchionni L, Fiorini C, Schneider C, Hosoda T, Rota M, Kajstura J, Anversa P, Beltrami CA, Leri A. Effects of age and heart failure on human cardiac stem cell function. Am J Pathol. 2011;179(1):349-366.
36. Beltrami AP, Cesselli D, Beltrami CA. At the stem of youth and health. Pharmacol Ther. 2011;129(1):3-20.
37. Kajstura J, Gurusamy N, Ogorek B, Goichberg P, Clavo-Rondon C, Hosoda T, D'Amario D, Bardelli S, Beltrami AP, Cesselli D, Bussani R, del Monte F, Quaini F, Rota M, Beltrami CA, Buchholz BA, Leri A, Anversa P. Myocyte turnover in the aging human heart. Circ Res. 2010;107(11):1374-1386.
38. Fortini C, Toffoletto B, Fucili A, Puppato E, Olivares A, Beltrami AP, Fiorelli V, Bergamin N, Cesselli D, Morelli C, Francolini G, Ferrari R, Beltrami CA. Circulating stem cell vary with NYHA stage in heart failure patients. J Cell Mol Med. 2010;15(8):1726-1736.
39. Ferro F, Falini G, Spelat R, D'Aurizio F, Puppato E, Pandolfi M, Beltrami AP, Cesselli D, Beltrami CA, Impiombato FS, Curcio F. Biochemical and biophysical analyses of tissue-engineered bone obtained from three-dimensional culture of a subset of bone marrow mesenchymal stem cells. Tissue Eng Part A. 2010;16(12):3657-3667.
40. Corallini F, Secchiero P, Beltrami AP, Cesselli D, Puppato E, Ferrari R, Beltrami CA, Zauli G. TNF-alpha modulates the migratory response of mesenchymal stem cells to TRAIL. Cell Mol Life Sci. 2010;67(8):1307-1314.
41. Campagnolo P, Cesselli D, Al Haj Zen A, Beltrami AP, Krankel N, Katare R, Angelini G, Emanueli C, Madeddu P. Human adult vena saphena contains perivascular progenitor cells endowed with clonogenic and proangiogenic potential. Circulation. 2010;121(15):1735-1745.
42. Kostic I, Toffoletto B, Fontanini E, Moretti M, Cesselli D, Beltrami CA, Ambesi Impiombato FS, Curcio F. Influence of iodide excess and interferon-gamma on human primary thyroid cell proliferation, thyroglobulin secretion, and intracellular adhesion molecule-1 and human leukocyte antigen-DR expression. Thyroid. 2009;19(3):283-291.
43. Cesselli D, Beltrami AP, Rigo S, Bergamin N, D'Aurizio F, Verardo R, Piazza S, Klaric E, Fanin R, Toffoletto B, Marzinotto S, Mariuzzi L, Finato N, Pandolfi M, Leri A, Schneider C, Beltrami CA, Anversa P. Multipotent progenitor cells are present in human peripheral blood. Circ Res. 2009;104(10):1225-1234.
44. Biagioli M, Pinto M, Cesselli D, Zaninello M, Lazarevic D, Roncaglia P, Simone R, Vlachouli C, Plessy C, Bertin N, Beltrami A, Kobayashi K, Gallo V, Santoro C, Ferrer I, Rivella S, Beltrami CA, Carninci P, Raviola E, Gustincich S. Unexpected expression of alpha- and beta-globin in mesencephalic dopaminergic neurons and glial cells. Proc Natl Acad Sci U S A. 2009;106(36):15454-15459.
45. Beltrami AP, Cesselli D, Beltrami CA. Pluripotency rush! Molecular cues for pluripotency, genetic reprogramming of adult stem cells, and widely multipotent adult cells. Pharmacol Ther. 2009;124(1):23-30.
46. Secchiero P, Melloni E, Corallini F, Beltrami AP, Alviano F, Milani D, D'Aurizio F, di Iasio MG, Cesselli D, Bagnara GP, Zauli G. Tumor necrosis factor-related apoptosis-inducing ligand promotes migration of human bone marrow multipotent stromal cells. Stem Cells. 2008;26(11):2955-2963.
47. Beltrami AP, Cesselli D, Bergamin N, Marcon P, Rigo S, Puppato E, D'Aurizio F, Verardo R, Piazza S, Pignatelli A, Poz A, Baccarani U, Damiani D, Fanin R, Mariuzzi L, Finato N, Masolini P, Burelli S, Belluzzi O, Schneider C, Beltrami CA. Multipotent cells can be generated in vitro from several adult human organs (heart, liver, and bone marrow). Blood. 2007;110(9):3438-3446.
48. Urbanek K, Cesselli D, Rota M, Nascimbene A, De Angelis A, Hosoda T, Bearzi C, Boni A, Bolli R, Kajstura J, Anversa P, Leri A. Stem cell niches in the adult mouse heart. Proc Natl Acad Sci U S A. 2006;103(24):9226-9231.
49. Muller P, Beltrami AP, Cesselli D, Pfeiffer P, Kazakov A, Bohm M. Myocardial regeneration by endogenous adult progenitor cells. J Mol Cell Cardiol. 2005;39(2):377-387.
50. Beltrami AP, Cesselli D, Bergamin N, Marcon P, Rigo S, Burelli S, Puppato E, D'Aurizio F, Bottecchia M, Masolini P, Mariuzzi L, Finato N, Beltrami CA. Investigation on possible cell sources to be utilized for cardiac cell therapy. Pathologica. 2005;97(4):185.
51. Fiordaliso F, Leri A, Cesselli D, Limana F, Safai B, Nadal-Ginard B, Anversa P, Kajstura J. Hyperglycemia activates p53 and p53-regulated genes leading to myocyte cell death. Diabetes. 2001;50(10):2363-2375.
52. Cesselli D, Jakoniuk I, Barlucchi L, Beltrami AP, Hintze TH, Nadal-Ginard B, Kajstura J, Leri A, Anversa P. Oxidative stress-mediated cardiac cell death is a major determinant of ventricular dysfunction and failure in dog dilated cardiomyopathy. Circ Res. 2001;89(3):279-286.
53. Tell G, Pellizzari L, Pucillo C, Puglisi F, Cesselli D, Kelley MR, Di Loreto C, Damante G. TSH controls Ref-1 nuclear translocation in thyroid cells. J Mol Endocrinol. 2000;24(3):383-390.
54. Puglisi F, Cesselli D, Damante G, Pellizzari L, Beltrami CA, Di Loreto C. Expression of Pax-8, p53 and bcl-2 in human benign and malignant thyroid diseases. Anticancer Res. 2000;20(1A):311-316.
5 chapters in international peer-reviewed books:
- Cesselli D, Beltrami AP, et al. (2013). Human Low Grade Glioma Cultures. In: Diffuse Low-Grade Gliomas in Adults. Springer, ISBN: 978-1-4471-2212-8.
- C. Avellini, D. Cesselli, A.P. et al. (2013). Conditions that Predispose to the Development of HCC: The Role of Tumor Associated Fibroblasts and of microRNA, Hepatocellular Carcinoma - Future Outlook, Dr. Ahmed Kaseb (Ed.), ISBN: 978-953-51-1202-0, InTech, DOI: 10.5772/56951.
- Cesselli D, D’Aurizio F, et al. (2013). Cardiac Stem Cell Senescence. In: Stem Cells and Aging. New York: Springer - Humana press, ISBN: 978-1-62703-316-9. DOI: 10.1007/978-1-62703-317-6_7.
- Cesselli D, Caragnano A, et al. (2012). Pharmacologic Inhibition of Cardiac Stem Cell Senescence, Senescence, Dr. Tetsuji Nagata (Ed.), ISBN: 978-953-51-0144-4, InTech, DOI: 10.5772/33732.
- Beltrami AP, Cesselli D, Beltrami CA (2011). Multiple Sources for Cardiac Stem Cells and Their Cardiogenic Potential. Regenerating the Heart. In: Cohen IS, Gaudette GR, eds. Regenerating the Heart: Humana Press; 2011:149-171. ISBN 978-1-61779-021-8. DOI 10.1007/978-1-61779-021-8_10.
INVITED SPEAKER AT INTERNATIONAL EVENTS (2010-2016)
- "Rebuilding the Failing Heart" - Lugano, 9th-10th May 2016.
- DEPArray™ User Meeting. Bologna 10th-11th 2015. http://www.siliconbiosystems.com/deparray-user-meeting-program-1
- DEPArray™ User Meeting. Bologna 2nd-3rd December 2014. http://www.siliconbiosystems.com/deparray-user-meeting-home.
- Advanced School on Synchrotron Radiation Techniques and Nanotechnology: A Synergic Approach to Life Sciences and Medicine. Cape Town Campus, Stellenbosch, South Africa. 11th-22nd November 2013. Research Seminar: Rare Cell Detection. Summer school.
- 7th Conference on Experimental and Translational Oncology. 20th - 24th April 2013, Portoroz, Slovenia. Title: “Glioma-associated stem cells predict prognosis of human low-grade gliomas”.
- Modern Approaches to Research and Treatment of Cancer (Part A). 24th - 28th April, 2013 in Piran, Slovenia. Title: “Tumour-supporting Stromal Stem Cells in Low- and High-grade Gliomas”. Summer school.
- Meeting: "Basic research, diagnosis and clinics of the Niemann Pick type C disease in Italy" Udine, 26th June 2013. Title of the presentation: “Animal and cellular model of NPC”. ECM accreditation.
- The European CLINAM & ETPN Summit, Basel, June 23rd-26th, 2013. “Nanotechnology application to a novel cell based personalized in vitro model of neurodegenerative diseases”.
- Joint ICTP-KFAS Conference on Nanotechnology for Biological and Biomedical Applications (Nano-Bio-Med), 10 - 14 October 2011, Miramare, Trieste – Italy. Title: “ADVANCES AND PROSPECTS OF NANOTECHNOLOGY IN STEM CELL”.
- 3rd Notthingam Image Analysis Training School, Practical Image Analysis in Pathology. Dipartimento di Scienze Matematiche e Informatiche con il patrocinio della Facoltà di Medicina dell’Università degli Studi di Udine. 23-24 Giugno 2011. Title: “A case study: easy fluorescence quantification”.
Scientific Collaborations
Department of Medical and Biological Sciences: Dr. Miriam Isola, PhD; Prof. Irene Mavelli, PhD; Dr. Cinzia Puppin, PhD; Dr. Valentina Rapozzi, PhD; Prof. Francesco Curcio, MD; Prof. Fabio Puglisi, MD PHD; Prof. Gianluca Tell, PhD; Prof. CE Pucillo, MD, PhD; Dr. Gaetano Vitale, PhD.
University Hospital of Udine: Dr. Miran Skrap,MD,Dr. Tamara Ius, MD PhD,Neurosurgery Department; Prof. Ugolino Livi, Cardiosurgery Department; Prof. Fabio Puglisi, MD PhD, Oncology Department; Prof. Pier Camillo Parodi, Dr. Lara Lazzaro, MD, PhD, Clinic of Plastic Surgery; Dr. Bruno Bembi, MD, Dr. Andrea Dardis, PhD, Regional Coordination Centre for Rare Diseases
Italian collaborations: ICGEB Trieste (Director M. Giacca): Dr. Serena Zacchigna, MD PhD, Staff Research Scientist, Molecular Medicine; CIB/LNCIB Trieste (Director C. Schneider): Dr. Roberto Verardo, PhD; Dr. Silvano Piazza, PhD; Dr. Francesca De Marchi, PhD; ELETTRA Sincrotrone Trieste: Dr. Loredana Casalis, PhD, Coordinator of the NanoInnovationLAB; Dr. Pietro Parisse, PhD,INSTM - ST Unit Post-Doc; Dr. Paola Storici, PhD, Senior Research Scientist; CNR-IOM Basovizza Trieste, Dr. Marco Lazzarino, PhD, Scientist; Dr. Laura Andolfi,PhD, Post-Doc; Dr. Dan Cojoc, PhD, Senior Scientist; IOV, Padova: Dr. Rita Zamarchi, MD; Institute of Applied Genomics:Prof. M. Morgante,PhD,Director; Dr. Federica Cattonaro, PhD, Lab Director; IRCCS Foundation Institute for Neurology "Carlo Besta", IFOM-IEO-Campus, Milan, Italy: Dr. Silke Krol, PhD; University of Ferrara: Prof. Roberto Ferrari, MDPhD,Department of Medical Sciences; University of Trieste: Prof. Maurizio Prato, PhD and Dr. Tatiana Da Ros, PhD, Carbon Nanotechnology Group; Guidalberto Manfioletti, PhD, DSV; University of Verona: Prof. Marco Colombatti, MD and Dr. Giulio Fracasso, PhD, Department of Pathology and Diagnostics.
International collaborations: Prof. P. Madeddu, MD, Chair of Experimental Cardiovascular Medicine and Head of the Section of Regenerative Medicine, School of Medicine, University of Bristol, UK; Prof. Costanza Emanueli, PhD, Professorial Research Fellow in Vascular Pathology & Regeneration, Bristol Heart Institute, School of Clinical Sciences, University of Bristol, UK; Prof. Tamara Lah Turnsek, Ph.D, Director of the National Institute of Biology, Slovenia; Prof. Radovan Komel, PhD,University of Ljubljana, Medical Center for Molecular Biology, Slovenia; Prof. Ario de Marco, PhD, University of Nova Gorica, Center for biomedical sciences and engineering, Slovenia; Istitute Curie, Paris, France; Dr. Enrico Ferrari, PhD,Senior Lecturer, School of Life Sciences, College of Science, University of Lincoln, UK; Prof. Alessandro Vindigni, PhD,Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St. Louis, Missouri, USA.
GRANT ACTIVITY (2010-2015)
Principal Investigator
- Italian Ministry of Health: “Young Investigator”. “Employment of Adipose tissue derived Multipotent Adult Stem Cells for cardiovascular regeneration”. GR-2007-683407. € 600.000. 4 Operative Units (University of Udine, LNCIB, ICGEB, Scuola Sant’Anna).
Contribution to the writing and execution of the following
- Advanced Grant ”Molecular Nanotechnology For Life Science Application: QUantitative Interactomics for Diagnostics, Proteomics and QUantitative Oncology, (Quidroquo-QPQ-) proposal n. 269025. P.I. Prof. G. Scoles
- AIRC 5 per mille. Title: “Application of Advanced Nanotechnology in the Development of Innovative Cancer Diagnostics Tools”. Rif. 12214. 2012-2014. PI G. Toffoli. Project Partner: CA Beltrami (University of Udine).
- Programma per la Cooperazione Transfrontaliera Italia-Slovenia 2007-2013. Title: “Identificazione di nuovi marcatori di cellule staminali tumorali a scopo diagnostico e terapeutico”. 2011-2013. Coordinator: Tamara Lah (NIB Lubiana). Project Partner CA Beltrami (Azienda Ospedaliero University of Udine).
- FIRB Accordi di programma 2011. Title: “FIERCE – FInd nEw moleculaR and CEllular targets against cancer”. Pr. RBAP11Z4Z9. 2012-2014. Coordinator: M. Giacca (ICGEB). Project Partner CA Beltrami (University of Udine).
- FIRB accordi di programma 2011 pr. RBAP11ETKA_007 “Nanotechnological approaches for tumor theragnostic”. Coordinator: Maurizio Prato. Project Partner AP Beltrami (Università di Udine).
DIDACTIC ACTIVITIES.
- Medicine and Surgery, One-long cycle 2nd Degree course. Official teaching: Anatomical Pathology, S.S.D. MED/08 (2012-today).
- Health Biotechnologies (Biotecnologie Sanitarie), 2nd Level Degree Course. Integrated course of Regenerative Medicine. Official teaching: Reconstruction of tissues and organs - Biotechnological products for diagnostics, imaging and thearpy S.S.D. MED/08 (2009-2010); Experimental and diagnostic techniques - S.S.D. MED/08 (2012-2014; 2015-today).
- Degree in Obstetrics (for certified professional obstetricians) [772] (L2 - DM270). Integrated course principles of oncology, breast and sexology. Official teaching: Anatomical Pathology, S.S.D. MED/08 (2014/2015).
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- Bachelor in BIOMEDICAL LABORATORY TECHNIQUES. Integrated course of histopathology and cytopathology. Official teaching: Anatomical Pathology, S.S.D. MED/08 (2009/2010).